| Literature DB >> 16860559 |
Bulbul Pandit1, Yanjun Sun, Ping Chen, Dan L Sackett, Zhigen Hu, Wendy Rich, Chenglong Li, Andrew Lewis, Kevin Schaefer, Pui-Kai Li.
Abstract
A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported.Entities:
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Year: 2006 PMID： 16860559 DOI： 10.1016/j.bmc.2006.06.017
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641