| Literature DB >> 16860321 |
Maya Ilouze1, Arnon Dishon, Tamar Kahan, Moshe Kotler.
Abstract
A large DNA virus, designated koi herpes virus (KHV), carp interstitial nephritis gill necrosis virus (CNGV) and Cyprinid herpes virus-3 (CyHV-3), causes massive mortality of carp. Morphologically, the virus resembles herpes viruses, but it contains a genome of ca 295 kbp, larger than that of any Herpesviridae member. Interestingly, three CyHV-3 genes, thymidylate monophosphate kinase (TmpK), ribonucleotide reductase and thymidine kinase, which are involved in deoxynucleotide tri-phosphate synthesis, resemble those of pox viruses. In addition to the TmpK gene, which is nonexistent in the genome of herpes viruses, CyHV-3 contains a B22R-like gene, exclusively expressed by pox viruses. These results raise questions on the phylogenic origin of CyHV-3.Entities:
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Year: 2006 PMID： 16860321 DOI： 10.1016/j.febslet.2006.07.013
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124