| Literature DB >> 16859998 |
Kelly L Summers1, Annette M Marleau, Jeffrey L Mahon, Ruth McManus, Irene Hramiak, Bhagirath Singh.
Abstract
Characterization of dendritic cells (DC) in human diabetes has been restricted to monocyte-derived DC in type 1 diabetes, whose physiological relevance to endogenous DC is uncertain. Here, we provide the first report characterizing the phenotype and function of endogenous DC subsets in type 1 and type 2 diabetes. We show that DC subsets in each diabetic group exhibit normal properties concerning frequency and activation state, as determined using 4-color flow cytometry of whole blood cells. DC maturation is also intact as confirmed by their efficacious ability to stimulate T cell proliferation in an allogeneic MLR assay. Yet we found that DC are poor producers of IFN-alpha (P < 0.05) in human diabetes. IFN-alpha is a potent antiviral agent and therefore its reduced levels may interfere with T cell-mediated immune responses leading to increased susceptibility and persistence of infections in persons with diabetes.Entities:
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Year: 2006 PMID： 16859998 DOI： 10.1016/j.clim.2006.05.015
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969