Literature DB >> 16858473

Response of intractable post herpetic neuralgia to intrathecal baclofen.

Amr Hosny1, Thomas Simopoulos, Beth Collins.   

Abstract

An intractable case of Post-herpetic Neuralgia (PHN) in which all other treatment options were exhausted was successfully treated with intrathecal baclofen infusion with a complex continuous delivery mode. A 72-year old man presented to the pain clinic with a 4-year history of left lower extremity PHN. He had seen multiple experts in the field, failed numerous pharmacological therapies, and interventional techniques. After multiple neuraxial medications were tried, baclofen was chosen and an intrathecal drug delivery system was implanted. Eight months after the procedure he continues to have 80 % pain relief. PHN is a devastating complication of shingles. Fortunately, most cases respond to conventional therapies. For intractable cases intrathecal baclofen appears to be a safe and effective therapeutic modality.

Entities:  

Year:  2004        PMID: 16858473

Source DB:  PubMed          Journal:  Pain Physician        ISSN: 1533-3159            Impact factor:   4.965


  3 in total

1.  Intrathecal medications in post-herpetic neuralgia.

Authors:  Andrew J Fabiano; Carolyn Doyle; Robert J Plunkett
Journal:  Pain Med       Date:  2012-05-23       Impact factor: 3.750

Review 2.  GABAB Receptors and Pain.

Authors:  Dietmar Benke
Journal:  Curr Top Behav Neurosci       Date:  2022

3.  Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo.

Authors:  Vijayan Gangadharan; Nitin Agarwal; Stefan Brugger; Imgard Tegeder; Bernhard Bettler; Rohini Kuner; Martina Kurejova
Journal:  Mol Pain       Date:  2009-11-19       Impact factor: 3.395

  3 in total

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