Literature DB >> 16858245

Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin.

Enzo Hrovatin1, Elda Viel, Chiara Lestuzzi, Lucia Tartuferi, Fabio Zardo, Marco Brieda, Ermanno Dametto, Rita Piazza, Francesco Antonini-Canterin, Elda Vaccher, Nereo Meneguzzo, Gian Luigi Nicolosi.   

Abstract

The antimetabolite 5-fluorouracil is frequently used in the therapy of various malignancies. Cardiotoxicity has frequently been described during treatment, but there is no common agreement on the need to perform cardiovascular monitoring of patients during 5-fluorouracil administration. We report the case of a young patient with an head-neck cancer on whom a continuous electrocardiogram recording was performed, documenting serious ventricular dysrhythmias in the presence of myocardial ischemia during 5-fluorouracil and cis-platin infusion.

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Year:  2006        PMID： 16858245     DOI： 10.2459/01.JCM.0000237914.12915.dd

Source DB:  PubMed          Journal:  J Cardiovasc Med (Hagerstown)        ISSN： 1558-2027            Impact factor:   2.160


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