| Literature DB >> 16857582 |
Lance D Langston1, Mike O'Donnell.
Abstract
As the replication fork progresses, synthesis of the discontinuous lagging strand requires frequent priming and cycling of the lagging strand polymerase to the new primers. It appears that this mechanism also permits bypass of template lesions on both strands, leaving the damage behind in a single-strand gap and precluding fork stalling or collapse.Mesh:
Substances:
Year: 2006 PMID: 16857582 DOI: 10.1016/j.molcel.2006.05.034
Source DB: PubMed Journal: Mol Cell ISSN: 1097-2765 Impact factor: 17.970