Literature DB >> 16857427

NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.

Alain Israël1.   

Abstract

Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.

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Year:  2006        PMID： 16857427     DOI： 10.1016/j.it.2006.07.003

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  10 in total

1.  Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.

Authors:  Ryusuke Yoshimi; Tsung-Hsien Chang; Hongsheng Wang; Toru Atsumi; Herbert C Morse; Keiko Ozato
Journal:  J Immunol       Date:  2009-06-15       Impact factor: 5.422

Review 2.  Ubiquitination in signaling to and activation of IKK.

Authors:  Zhijian J Chen
Journal:  Immunol Rev       Date:  2012-03       Impact factor: 12.988

Review 3.  Expanding role of ubiquitination in NF-κB signaling.

Authors:  Siqi Liu; Zhijian J Chen
Journal:  Cell Res       Date:  2010-12-07       Impact factor: 25.617

4.  TAK1-dependent signaling requires functional interaction with TAB2/TAB3.

Authors:  Arnaud Besse; Betty Lamothe; Alejandro D Campos; William K Webster; Upendra Maddineni; Su-Chang Lin; Hao Wu; Bryant G Darnay
Journal:  J Biol Chem       Date:  2006-12-08       Impact factor: 5.157

Review 5.  Ubiquitin in NF-kappaB signaling.

Authors:  Yu-Hsin Chiu; Meng Zhao; Zhijian J Chen
Journal:  Chem Rev       Date:  2009-04       Impact factor: 60.622

6.  NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.

Authors:  E Laplantine; E Fontan; J Chiaravalli; T Lopez; G Lakisic; M Véron; F Agou; Alain Israël
Journal:  EMBO J       Date:  2009-09-17       Impact factor: 11.598

7.  A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

Authors:  Ming Xu; Brian Skaug; Wenwen Zeng; Zhijian J Chen
Journal:  Mol Cell       Date:  2009-10-23       Impact factor: 17.970

8.  The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.

Authors:  Ji Young Kim; Keiko Ozato
Journal:  J Immunol       Date:  2009-02-15       Impact factor: 5.422

Review 9.  Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury.

Authors:  Christer Baeck; Frank Tacke
Journal:  EXCLI J       Date:  2014-02-07       Impact factor: 4.068

10.  Molecular changes associated with increased TNF-α-induced apoptotis in naïve (TN) and central memory (TCM) CD8+ T cells in aged humans.

Authors:  Sudhir Gupta; Houfen Su; Sudhanshu Agrawal; Sastry Gollapudi
Journal:  Immun Ageing       Date:  2018-01-19       Impact factor: 6.400
  10 in total

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