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Literature DB >> 16856853

Human polymorphism around recombination hotspots.

Abstract

Meiotic recombination in humans is thought to occur as part of the resolution of DSBs (double-strand breaks). The repair of DSBs potentially leads to biases in DNA repair that can distort the population frequency of the alleles at single-nucleotide polymorphisms. Genome-wide variation data provide evidence for a weak fixation bias in favour of G and C alleles that is strongest at the centre of inferred recombination hotspots.

Entities: Species

Mesh：

Substances：
Nucleotides

Year: 2006 PMID： 16856853 DOI： 10.1042/BST0340535

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

9 in total

1. Detecting positive selection within genomes: the problem of biased gene conversion.

Authors: Abhirami Ratnakumar; Sylvain Mousset; Sylvain Glémin; Jonas Berglund; Nicolas Galtier; Laurent Duret; Matthew T Webster
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2010-08-27 Impact factor: 6.237

2. Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.

Authors: Jonathan Romiguier; Vincent Ranwez; Emmanuel J P Douzery; Nicolas Galtier
Journal: Genome Res Date: 2010-06-07 Impact factor: 9.043

3. The GC-rich mitochondrial and plastid genomes of the green alga Coccomyxa give insight into the evolution of organelle DNA nucleotide landscape.

Authors: David Roy Smith; Fabien Burki; Takashi Yamada; Jane Grimwood; Igor V Grigoriev; James L Van Etten; Patrick J Keeling
Journal: PLoS One Date: 2011-08-26 Impact factor: 3.240

4. The influence of genomic context on mutation patterns in the human genome inferred from rare variants.

Authors: Valerie M Schaibley; Matthew Zawistowski; Daniel Wegmann; Margaret G Ehm; Matthew R Nelson; Pamela L St Jean; Gonçalo R Abecasis; John Novembre; Sebastian Zöllner; Jun Z Li
Journal: Genome Res Date: 2013-08-29 Impact factor: 9.043

5. Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome.

Authors: Erika M Kvikstad; Laurent Duret
Journal: Mol Biol Evol Date: 2013-10-09 Impact factor: 16.240

Human polymorphism around recombination hotspots.

1. Detecting positive selection within genomes: the problem of biased gene conversion.

2. Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.

3. The GC-rich mitochondrial and plastid genomes of the green alga Coccomyxa give insight into the evolution of organelle DNA nucleotide landscape.

4. The influence of genomic context on mutation patterns in the human genome inferred from rare variants.

5. Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome.

6. Germline methylation patterns determine the distribution of recombination events in the dog genome.

7. Analytical Biases Associated with GC-Content in Molecular Evolution.

Review 8. Codon usage and codon pair patterns in non-grass monocot genomes.

9. The impact of recombination on nucleotide substitutions in the human genome.