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Literature DB >> 16856850

Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.

Abstract

Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.

Entities: Gene

Mesh：

Substances：
DNA

Year: 2006 PMID： 16856850 DOI： 10.1042/BST0340523

Source DB: PubMed Journal: Biochem Soc Trans ISSN： 0300-5127 Impact factor: 5.407

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Cited

98 in total

1. Robustness in crossover regulation during meiosis.

Authors: Chitra V Kotwaliwale
Journal: Nat Cell Biol Date: 2012-04-02 Impact factor: 28.824

2. Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.

Authors: Pengfei Liu; Melanie Lacaria; Feng Zhang; Marjorie Withers; P J Hastings; James R Lupski
Journal: Am J Hum Genet Date: 2011-10-07 Impact factor: 11.025

3. Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.

Authors: Amitabh V Nimonkar; Christopher C Dombrowski; Joseph S Siino; Alicja Z Stasiak; Andrzej Stasiak; Stephen C Kowalczykowski
Journal: J Biol Chem Date: 2012-06-29 Impact factor: 5.157

Review 4. Mechanisms and regulation of DNA end resection.

Authors: Maria Pia Longhese; Diego Bonetti; Nicola Manfrini; Michela Clerici
Journal: EMBO J Date: 2010-07-20 Impact factor: 11.598

5. DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.

Authors: Nataliya E Yelina; Christophe Lambing; Thomas J Hardcastle; Xiaohui Zhao; Bruno Santos; Ian R Henderson
Journal: Genes Dev Date: 2015-10-15 Impact factor: 11.361

Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.

1. Robustness in crossover regulation during meiosis.

2. Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.

3. Saccharomyces cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins, respectively, to promote DNA strand invasion during genetic recombination.

Review 4. Mechanisms and regulation of DNA end resection.

5. DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.

Review 6. Meiotic Recombination: The Essence of Heredity.

7. Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery.

8. Mechanisms of leukemia translocations.

9. AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana.

10. Dissecting meiosis of rye using translational proteomics.