Literature DB >> 16856846

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.

M Mongillo1, M Zaccolo.   

Abstract

beta-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 family variants. Each PDE family is characterized by unique functional properties and contributes to a cAMP-degrading system enabling the modulation of PKA activity in a stimulus-dependent fashion.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16856846     DOI： 10.1042/BST0340510

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  14 in total

1.  Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.

Authors:  Vania De Arcangelis; Shubai Liu; Dawen Zhang; Dagoberto Soto; Yang K Xiang
Journal:  Mol Pharmacol       Date:  2010-06-07       Impact factor: 4.436

2.  Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation.

Authors:  Chia-Wei Jenny Chang; Linda Lee; David Yu; Khanha Dao; Julie Bossuyt; Donald M Bers
Journal:  J Biol Chem       Date:  2012-11-16       Impact factor: 5.157

3.  A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies.

Authors:  Pernilla von Nandelstadh; Mohamed Ismail; Chiara Gardin; Heli Suila; Ivano Zara; Anna Belgrano; Giorgio Valle; Olli Carpen; Georgine Faulkner
Journal:  Mol Cell Biol       Date:  2008-12-01       Impact factor: 4.272

4.  Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor.

Authors:  Vania De Arcangelis; Dagoberto Soto; Yang Xiang
Journal:  Mol Pharmacol       Date:  2008-08-14       Impact factor: 4.436

5.  Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function.

Authors:  Yevgeniya O Lukyanenko; Antoine Younes; Alexey E Lyashkov; Kirill V Tarasov; Daniel R Riordon; Joonho Lee; Syevda G Sirenko; Evgeny Kobrinsky; Bruce Ziman; Yelena S Tarasova; Magdalena Juhaszova; Steven J Sollott; David R Graham; Edward G Lakatta
Journal:  J Mol Cell Cardiol       Date:  2016-06-27       Impact factor: 5.000

6.  Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.

Authors:  Honglan Wang; Mark J Kohr; Christopher J Traynham; Mark T Ziolo
Journal:  J Mol Cell Cardiol       Date:  2009-04-01       Impact factor: 5.000

7.  Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.

Authors:  Matthew D Bruss; Wito Richter; Kathleen Horner; S-L Catherine Jin; Marco Conti
Journal:  J Biol Chem       Date:  2008-05-28       Impact factor: 5.157

8.  Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans.

Authors:  Shaquria P Adderley; Eileen A Dufaux; Meera Sridharan; Elizabeth A Bowles; Madelyn S Hanson; Alan H Stephenson; Mary L Ellsworth; Randy S Sprague
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-02-27       Impact factor: 4.733

9.  Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5.

Authors:  Shaquria P Adderley; Kelly M Thuet; Meera Sridharan; Elizabeth A Bowles; Alan H Stephenson; Mary L Ellsworth; Randy S Sprague
Journal:  Med Sci Monit       Date:  2011-05

Review 10.  Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins.

Authors:  Ana I Calejo; Kjetil Taskén
Journal:  Front Pharmacol       Date:  2015-09-08       Impact factor: 5.810
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.