Literature DB >> 16855686

Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model.

Grant E Boldt1, Lisa M Eubanks, Kim D Janda.   

Abstract

Herein we describe a small-molecule, non-peptidic, inhibitor for botulinum neurotoxin A protease, that displays for the first time efficacy in a cell-based assay.

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Year:  2006        PMID： 16855686     DOI： 10.1039/b603099h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

1.  An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

Authors:  Lisa M Eubanks; Mark S Hixon; Wei Jin; Sukwon Hong; Colin M Clancy; William H Tepp; Michael R Baldwin; Carl J Malizio; Michael C Goodnough; Joseph T Barbieri; Eric A Johnson; Dale L Boger; Tobin J Dickerson; Kim D Janda
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-09       Impact factor: 11.205

2.  Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.

Authors:  Baskaran Thyagarajan; Joseph G Potian; Carmen C Garcia; Kormakur Hognason; Katerina Capková; Scott T Moe; Alan R Jacobson; Kim D Janda; Joseph J McArdle
Journal:  Neuropharmacology       Date:  2010-03-06       Impact factor: 5.250

3.  Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.

Authors:  Alan R Jacobson; Michael Adler; Nicholas R Silvaggi; Karen N Allen; Genessa M Smith; Ross A Fredenburg; Ross L Stein; Jong-Beak Park; Xiaochuan Feng; Charles B Shoemaker; Sharad S Deshpande; Michael C Goodnough; Carl J Malizio; Eric A Johnson; Sabine Pellett; William H Tepp; Saul Tzipori
Journal:  Toxicon       Date:  2017-07-08       Impact factor: 3.033

4.  Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.

Authors:  Martha Hale; George Oyler; Subramanyam Swaminathan; S Ashraf Ahmed
Journal:  J Biol Chem       Date:  2010-10-20       Impact factor: 5.157

5.  Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.

Authors:  Bing Li; Ramdas Pai; Steven C Cardinale; Michelle M Butler; Norton P Peet; Donald T Moir; Sina Bavari; Terry L Bowlin
Journal:  J Med Chem       Date:  2010-03-11       Impact factor: 7.446

6.  The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity.

Authors:  Shuowei Cai; Paul Lindo; Jong-Beak Park; Kruti Vasa; Bal Ram Singh
Journal:  Toxicon       Date:  2009-12-07       Impact factor: 3.033

7.  Small molecules showing significant protection of mice against botulinum neurotoxin serotype A.

Authors:  Yuan-Ping Pang; Jon Davis; Shaohua Wang; Jewn Giew Park; Madhusoodana P Nambiar; James J Schmidt; Charles B Millard
Journal:  PLoS One       Date:  2010-04-13       Impact factor: 3.240

8.  Function-oriented synthesis applied to the anti-botulinum natural product toosendanin.

Authors:  Yuya Nakai; William H Tepp; Tobin J Dickerson; Eric A Johnson; Kim D Janda
Journal:  Bioorg Med Chem       Date:  2008-12-25       Impact factor: 3.641

9.  Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).

Authors:  Yuya Nakai; Sabine Pellett; William H Tepp; Eric A Johnson; Kim D Janda
Journal:  Bioorg Med Chem       Date:  2009-12-22       Impact factor: 3.641

10.  Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.

Authors:  Yuan-Ping Pang; Anuradha Vummenthala; Rajesh K Mishra; Jewn Giew Park; Shaohua Wang; Jon Davis; Charles B Millard; James J Schmidt
Journal:  PLoS One       Date:  2009-11-10       Impact factor: 3.240
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