OBJECTIVES: Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important human infections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzi mouse model. METHODS: The trypanocidal activity of the compound was evaluated by clinical, parasitological, histopathological and biochemical investigations. RESULTS: Treatment with DB569 significantly reduced cardiac parasitism, partially increased the survival rates of mice and lowered the levels of alanine aminotransferase and creatinine indicating a protective role against renal and hepatic lesions caused by the parasite infection. CONCLUSIONS: Altogether, the data support the potential effect of this class of compounds against T. cruzi and motivate the screening of new diamidines for efficacy against Chagas' disease.
OBJECTIVES: Aromatic diamidines have been successfully used to combat a wide range of parasites that cause important humaninfections. One such compound is furamidine (DB75) and we recently reported that one of its analogues, an N-phenyl analogue (DB569), exhibits higher trypanocidal dose and time-dependent effects against different forms of Trypanosoma cruzi as compared with DB75. Our present aim was to investigate the efficacy of DB569 in a T. cruzimouse model. METHODS: The trypanocidal activity of the compound was evaluated by clinical, parasitological, histopathological and biochemical investigations. RESULTS: Treatment with DB569 significantly reduced cardiac parasitism, partially increased the survival rates of mice and lowered the levels of alanine aminotransferase and creatinine indicating a protective role against renal and hepatic lesions caused by the parasite infection. CONCLUSIONS: Altogether, the data support the potential effect of this class of compounds against T. cruzi and motivate the screening of new diamidines for efficacy against Chagas' disease.
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Authors: Cristiane França da Silva; Denise da Gama Jaen Batista; Julianna Siciliano De Araújo; Marcos Meuser Batista; Jessica Lionel; Elen Mello de Souza; Erica Ripoll Hammer; Patricia Bernardino da Silva; Maria De Mieri; Michael Adams; Stefanie Zimmermann; Matthias Hamburger; Reto Brun; Wolfgang Schühly; Maria de Nazaré Correia Soeiro Journal: Antimicrob Agents Chemother Date: 2013-08-12 Impact factor: 5.191
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Authors: Denise da Gama Jaén Batista; Marcos Meuser Batista; Gabriel Melo de Oliveira; Constança Carvalho Britto; Ana Carolina Mondaine Rodrigues; Chad E Stephens; David W Boykin; Maria de Nazaré Correia Soeiro Journal: PLoS One Date: 2011-07-26 Impact factor: 3.240