| Literature DB >> 16854613 |
Klaus Laimer1, Gilbert Spizzo, Guenther Gastl, Peter Obrist, Thomas Brunhuber, Dominic Fong, Verena Barbieri, Siegfried Jank, Wolfgang Doppler, Michael Rasse, Burghard Norer.
Abstract
This retrospective study was designed to investigate the prognostic significance of EGFR overexpression in human oral squamous cell carcinoma on a long-term follow-up. EGFR expression was examined immunohistochemically on a tissue microarray (TMA) of paraffin embedded tissue specimens from 109 patients who underwent surgical treatment for squamous cell carcinoma of the oral cavity and oropharynx in the period between 1980 and 1997. High EGFR expression was found in 80 (73.42%) of the tumour samples. Kaplan-Meier curves showed that EGFR overexpression was significantly related to decreased overall survival (p=0.05). Multivariate analysis showed that EGFR overexpression is an independent prognostic marker in these patients (p=0.02, RR 3.6). These results confirm that EGFR overexpression is an independent prognostic marker in patients with squamous cell carcinoma of the oral cavity and oropharynx. The EGFR antigen represents an attractive target for targeted therapies with monoclonal antibodies or specific tyrosine-kinase inhibitors in these patients.Entities:
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Year: 2006 PMID： 16854613 DOI： 10.1016/j.oraloncology.2006.02.009
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337