Literature DB >> 16854087

Synthesis and anti-hepatitis B virus activity of novel benzimidazole derivatives.

Yun-Fei Li1, Gui-Feng Wang, Pei-Lan He, Wei-Gang Huang, Feng-Hua Zhu, He-Yong Gao, Wei Tang, Yu Luo, Chun-Lan Feng, Li-Ping Shi, Yu-Dan Ren, Wei Lu, Jian-Ping Zuo.   

Abstract

A series of novel benzimidazole derivatives was synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in vitro. Strong activity against HBV replication and low cytotoxicity were generally observed in these benzimidazoles. The most promising compounds were 12a and 12b, with similar high antiviral potency (IC50 = 0.9 and 0.7 microM, respectively) and remarkable selectivity indices (>1111 and 714, respectively). They were selected for further evaluation as novel HBV inhibitors.

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Year:  2006        PMID： 16854087     DOI： 10.1021/jm060330f

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

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4.  Synthesis and insight into the structure-activity relationships of 2-phenylbenzimidazoles as prospective anticancer agents.

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Review 6.  Discovery and development of anti-HBV agents and their resistance.

Authors:  Kyun-Hwan Kim; Nam Doo Kim; Baik-Lin Seong
Journal:  Molecules       Date:  2010-08-27       Impact factor: 4.411

7.  Novel coumarin-benzimidazole derivatives as antioxidants and safer anti-inflammatory agents.

Authors:  Radha Krishan Arora; Navneet Kaur; Yogita Bansal; Gulshan Bansal
Journal:  Acta Pharm Sin B       Date:  2014-08-10       Impact factor: 11.413

8.  Synthesis of 99mTc-labeled 2-Mercaptobenzimidazole as a novel radiotracer to diagnose tumor hypoxia.

Authors:  Syed Faheem Askari Rizvi; Haixia Zhang; Sajid Mehmood; Mahmoud Sanad
Journal:  Transl Oncol       Date:  2020-08-28       Impact factor: 4.243
  8 in total

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