| Literature DB >> 16854085 |
Jin Hee Ahn1, Mi Sik Shin, Sun Ho Jung, Seung Kyu Kang, Kwang Rok Kim, Sang Dal Rhee, Won Hoon Jung, Sung Don Yang, Seung Jun Kim, Joo Rang Woo, Jeong Hyung Lee, Hyae Gyeong Cheon, Sung Soo Kim.
Abstract
Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.Entities:
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Year: 2006 PMID： 16854085 DOI： 10.1021/jm060389m
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446