Literature DB >> 1685321

Anti-HIV agents. I: Synthesis and in vitro anti-HIV evaluation of novel 1H,3H-thiazolo[3,4-a]benzimidazoles.

A Chimirri1, S Grasso, A M Monforte, P Monforte, M Zappalà.   

Abstract

A series of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles were synthesized by one-pot reaction from o-phenylenediamine, 2-mercaptoacetic acid and a variety of aromatic aldehydes. All compounds obtained were evaluated for antiviral activity against human immunodeficiency virus (HIV). Compounds 4g, 4i, 4j, 4l and 4q exhibit reproducible in vitro anti-HIV activity.

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Year:  1991        PMID： 1685321

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  6 in total

Review 1.  Antiviral therapy for human immunodeficiency virus infections.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  1995-04       Impact factor: 26.132

2.  Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors.

Authors:  A Hizi; R Tal; M Shaharabany; M J Currens; M R Boyd; S H Hughes; J B McMahon
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

3.  Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.

Authors:  P L Boyer; M J Currens; J B McMahon; M R Boyd; S H Hughes
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

4.  Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme.

Authors:  Marshall L Morningstar; Thomas Roth; David W Farnsworth; Marilyn Kroeger Smith; Karen Watson; Robert W Buckheit; Kalyan Das; Wanyi Zhang; Eddy Arnold; John G Julias; Stephen H Hughes; Christopher J Michejda
Journal:  J Med Chem       Date:  2007-07-31       Impact factor: 7.446

5.  Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase.

Authors:  D V Nissley; P L Boyer; D J Garfinkel; S H Hughes; J N Strathern
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

6.  Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions.

Authors:  El Sayed H El Ashry; Yeldez El Kilany; Nariman M Nahas; Assem Barakat; Nadia Al-Qurashi; Hazem A Ghabbour; Hoong-Kun Fun
Journal:  Molecules       Date:  2015-12-22       Impact factor: 4.411
  6 in total

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