BACKGROUND: The relationship between the state of non-cancerous tissues in patients with hepatocellular carcinoma (HCC) who are negative for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), and hepatitis C antibody (HCVAb) (NBNC-HCC) and the prognosis has not yet been resolved. METHODS: We examined the clinicopathological features of these patients and performed statistical analysis for the prognosis of recurrence following curative hepatic resection. RESULTS: Disease-free survival (DFS) revealed that only the degree of fibrosis was a significant prognostic factor (P = 0.0374). On the basis of the degree of fibrosis (New Inuyama Classification), patients with NBNC-HCC were divided into a non-fibrotic liver group (NF group; F0, n = 10) and a fibrotic liver group (FL group; F1-4, n = 34). The DFS rate in the NF group was significantly better than that in the FL group (P = 0.0408). In the NF group, only one patient recurred, while in the FL group, 21 patients had recurrences. In the FL group, intra-hepatic recurrence was frequently seen in both lobes within 2 years after the initial hepatic resection, while recurrences more than 2 years after the initial operation were mainly seen in the contralateral lobe. CONCLUSION: Histological assessment of the degree of fibrosis in the non-cancerous regions of NBNC-HCC may be useful not only for the selection of the appropriate treatment but also for the prediction of postoperative prognosis.
BACKGROUND: The relationship between the state of non-cancerous tissues in patients with hepatocellular carcinoma (HCC) who are negative for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (HBcAb), and hepatitis C antibody (HCVAb) (NBNC-HCC) and the prognosis has not yet been resolved. METHODS: We examined the clinicopathological features of these patients and performed statistical analysis for the prognosis of recurrence following curative hepatic resection. RESULTS: Disease-free survival (DFS) revealed that only the degree of fibrosis was a significant prognostic factor (P = 0.0374). On the basis of the degree of fibrosis (New Inuyama Classification), patients with NBNC-HCC were divided into a non-fibrotic liver group (NF group; F0, n = 10) and a fibrotic liver group (FL group; F1-4, n = 34). The DFS rate in the NF group was significantly better than that in the FL group (P = 0.0408). In the NF group, only one patient recurred, while in the FL group, 21 patients had recurrences. In the FL group, intra-hepatic recurrence was frequently seen in both lobes within 2 years after the initial hepatic resection, while recurrences more than 2 years after the initial operation were mainly seen in the contralateral lobe. CONCLUSION: Histological assessment of the degree of fibrosis in the non-cancerous regions of NBNC-HCC may be useful not only for the selection of the appropriate treatment but also for the prediction of postoperative prognosis.
Authors: M Shimada; T Rikimaru; K Sugimachi; T Hamatsu; Y Yamashita; S Aishima; K Taguchi; S Tanaka; K Shirabe; K Sugimachi Journal: J Am Coll Surg Date: 2000-11 Impact factor: 6.113
Authors: M M Bilimoria; G Y Lauwers; D A Doherty; D M Nagorney; J Belghiti; K A Do; J M Regimbeau; L M Ellis; S A Curley; I Ikai; Y Yamaoka; J N Vauthey Journal: Arch Surg Date: 2001-05
Authors: N Yamanaka; E Okamoto; T Oriyama; J Fujimoto; K Furukawa; E Kawamura; T Tanaka; F Tomoda Journal: Ann Surg Date: 1994-04 Impact factor: 12.969
Authors: Yan-Yan Zhang; Chao-Xu Zhang; Yu Li; Xuan Jiang; Yong-Fang Wang; Yang Sun; Jun Wang; Wan-Ying Ji; Yi Liu Journal: World J Gastroenterol Date: 2018-11-28 Impact factor: 5.742