RATIONALE: Although researchers now have a working knowledge of key brain structures involved in realization of actions of substance abuse and addiction, deeper understanding will require examination of network interactions between cortical neuronal assemblies and their subcortical tails in the effects of opioid dependence. OBJECTIVES: Given that repeated exposure to opiates initiates a widespread reorganization of cortical regions, we predict that opioid dependence would result in a considerable reorganization of local and remote functional connectivity in the neocortex. METHODS: We applied the novel operational architectonics approach that enables us to estimate two local and remote functional cortex connectivities by means of electroencephalogram structural synchrony measure. RESULTS: In 22 opioid-dependent patients, we found the evidence that brain functional connectivity was indeed disrupted by chronic opioid abuse (i.e., the local functional connectivity increased and remote functional connectivity decreased in opioid abusers). This significant difference between "opioid" and "control" populations was the same for alpha and beta frequency bands. Additionally, significant negative relations between duration (years) of daily opioid abuse and the number/strength of functional connections in the posterior section of the cortex were found.
RATIONALE: Although researchers now have a working knowledge of key brain structures involved in realization of actions of substance abuse and addiction, deeper understanding will require examination of network interactions between cortical neuronal assemblies and their subcortical tails in the effects of opioid dependence. OBJECTIVES: Given that repeated exposure to opiates initiates a widespread reorganization of cortical regions, we predict that opioid dependence would result in a considerable reorganization of local and remote functional connectivity in the neocortex. METHODS: We applied the novel operational architectonics approach that enables us to estimate two local and remote functional cortex connectivities by means of electroencephalogram structural synchrony measure. RESULTS: In 22 opioid-dependent patients, we found the evidence that brain functional connectivity was indeed disrupted by chronic opioid abuse (i.e., the local functional connectivity increased and remote functional connectivity decreased in opioid abusers). This significant difference between "opioid" and "control" populations was the same for alpha and beta frequency bands. Additionally, significant negative relations between duration (years) of daily opioid abuse and the number/strength of functional connections in the posterior section of the cortex were found.
Authors: Andrew A Fingelkurts; Alexander A Fingelkurts; Seppo Kähkönen Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2004-12-19 Impact factor: 5.067
Authors: Alexander A Fingelkurts; Andrew A Fingelkurts; Reetta Kivisaari; Taina Autti; Sergei Borisov; Varpu Puuskari; Olga Jokela; Seppo Kähkönen Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2006-08-04 Impact factor: 5.067
Authors: T J Ornstein; J L Iddon; A M Baldacchino; B J Sahakian; M London; B J Everitt; T W Robbins Journal: Neuropsychopharmacology Date: 2000-08 Impact factor: 7.853
Authors: Claudio Babiloni; Claudio Del Percio; Marina Boccardi; Roberta Lizio; Susanna Lopez; Filippo Carducci; Nicola Marzano; Andrea Soricelli; Raffaele Ferri; Antonio Ivano Triggiani; Annapaola Prestia; Serenella Salinari; Paul E Rasser; Erol Basar; Francesco Famà; Flavio Nobili; Görsev Yener; Derya Durusu Emek-Savaş; Loreto Gesualdo; Ciro Mundi; Paul M Thompson; Paolo M Rossini; Giovanni B Frisoni Journal: Neurobiol Aging Date: 2014-09-21 Impact factor: 4.673
Authors: Katherine W Scangos; Hasan S Ahmad; Alia Shafi; Kristin K Sellers; Heather E Dawes; Andrew Krystal; Edward F Chang Journal: J Neuropsychiatry Clin Neurosci Date: 2019-08-09 Impact factor: 2.198