Literature DB >> 16848693

Targeting adiponectin for cardioprotection.

Noriyuki Ouchi1, Rei Shibata, Kenneth Walsh.   

Abstract

Adiponectin is an adipose tissue-derived plasma protein which has a reduced concentration in subjects with obesity-related diseases. Adiponectin has antidiabetic and anti-inflammatory characteristics, which lead to beneficial actions on various obesity-linked complications. Recent experimental findings have shown that adiponectin contributes to protection against cardiac remodelling after pressure overload and cardiac injury following ischaemia-reperfusion. Thus, adiponectin could emerge as a potential cardioprotective agent for the treatment of several pathological heart conditions.

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Year:  2006        PMID： 16848693     DOI： 10.1517/14728222.10.4.573

Source DB:  PubMed          Journal:  Expert Opin Ther Targets        ISSN： 1472-8222            Impact factor:   6.902


  14 in total

1.  Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.

Authors:  Luca Vanella; Martina Canestraro; Craig R Lee; Jian Cao; Darryl C Zeldin; Michal L Schwartzman; Nader G Abraham
Journal:  Prostaglandins Other Lipid Mediat       Date:  2015-04-20       Impact factor: 3.072

2.  Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload.

Authors:  Karen M O'Shea; David J Chess; Ramzi J Khairallah; Sharad Rastogi; Peter A Hecker; Hani N Sabbah; Kenneth Walsh; William C Stanley
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-03-26       Impact factor: 4.733

3.  Restoring diabetes-induced autophagic flux arrest in ischemic/reperfused heart by ADIPOR (adiponectin receptor) activation involves both AMPK-dependent and AMPK-independent signaling.

Authors:  Yajing Wang; Bin Liang; Wayne Bond Lau; Yunhui Du; Rui Guo; Zheyi Yan; Lu Gan; Wenjun Yan; Jianli Zhao; Erhe Gao; Walter Koch; Xin-Liang Ma
Journal:  Autophagy       Date:  2017-09-01       Impact factor: 16.016

4.  Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.

Authors:  Yajing Wang; Xiaoliang Wang; Wayne Bond Lau; Yuexing Yuan; David Booth; Jing-Jing Li; Rosario Scalia; Kyle Preston; Erhe Gao; Walter Koch; Xin-Liang Ma
Journal:  Circ Res       Date:  2014-01-07       Impact factor: 17.367

Review 5.  Perivascular adipose tissue and coronary vascular disease.

Authors:  Meredith Kohr Owen; Jillian N Noblet; Daniel J Sassoon; Abass M Conteh; Adam G Goodwill; Johnathan D Tune
Journal:  Arterioscler Thromb Vasc Biol       Date:  2014-05-01       Impact factor: 8.311

6.  T-cadherin is essential for adiponectin-mediated revascularization.

Authors:  Jennifer L Parker-Duffen; Kazuto Nakamura; Marcy Silver; Ryosuke Kikuchi; Ulrich Tigges; Sumiko Yoshida; Martin S Denzel; Barbara Ranscht; Kenneth Walsh
Journal:  J Biol Chem       Date:  2013-07-03       Impact factor: 5.157

7.  AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin.

Authors:  Yajing Wang; Erhe Gao; Ling Tao; Wayne Bond Lau; Yuexin Yuan; Barry J Goldstein; Bernard L Lopez; Theodore A Christopher; Rong Tian; Walter Koch; Xin-Liang Ma
Journal:  Circulation       Date:  2009-02-02       Impact factor: 29.690

Review 8.  omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential.

Authors:  Monika K Duda; Karen M O'Shea; William C Stanley
Journal:  Cardiovasc Res       Date:  2009-05-27       Impact factor: 10.787

9.  Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.

Authors:  Monika K Duda; Karen M O'Shea; Anselm Tintinu; Wenhong Xu; Ramzi J Khairallah; Brian R Barrows; David J Chess; Agnes M Azimzadeh; William S Harris; Victor G Sharov; Hani N Sabbah; William C Stanley
Journal:  Cardiovasc Res       Date:  2008-11-17       Impact factor: 10.787

10.  C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation.

Authors:  Yang Sun; Wei Yi; Yuexing Yuan; Wayne Bond Lau; Dinghua Yi; Xiaoliang Wang; Yajing Wang; Hui Su; Xiaoming Wang; Erhe Gao; Walter J Koch; Xin-Liang Ma
Journal:  Circulation       Date:  2013-09-10       Impact factor: 29.690
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