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Literature DB >> 16848451

A selective fluorescent sensor for detecting lead in living cells.

Qiwen He¹, Evan W Miller, Audrey P Wong, Christopher J Chang.

Abstract

We present the synthesis, properties, and biological applications of Leadfluor-1 (LF1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively imaging Pb2+ in aqueous solution and in living cells. LF1 combines a fluorescein chromophore and a pseudocrown receptor to provide good selectivity for Pb2+ over a range of biologically and environmentally relevant metal ions in aqueous solution, with sensitivity to parts per billion EPA limits for allowable lead in drinking water. In addition to these attributes, imaging experiments further show that LF1 is the first small-molecule reagent that can be delivered into living cells and report changes in intracellular Pb2+ levels.

Entities: Chemical

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Year: 2006 PMID： 16848451 DOI： 10.1021/ja063029x

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

29 in total

1. Colorimetric Determination of Pb²⁺ in Perfect Aqueous Solution Using Carminic Acid as a Selective Chemosensor.

Authors: Masaru Sakamaki; Shunichi Aikawa; Yasumasa Fukushima
Journal: J Fluoresc Date: 2017-06-21 Impact factor: 2.217

Review 2. Fluorescent sensors for measuring metal ions in living systems.

Authors: Kyle P Carter; Alexandra M Young; Amy E Palmer
Journal: Chem Rev Date: 2014-03-03 Impact factor: 60.622

3. Carbamodithioate-based dual functional fluorescent probe for Hg(2+) and S(2-).

Authors: Xiaohong Cheng; Shuang Li; Zhicheng Zhong; Song Wang; Ping He
Journal: J Fluoresc Date: 2014-09-30 Impact factor: 2.217

4. Improved PeT molecules for optically sensing voltage in neurons.

Authors: Clifford R Woodford; E Paxon Frady; Richard S Smith; Benjamin Morey; Gabriele Canzi; Sakina F Palida; Ricardo C Araneda; William B Kristan; Clifford P Kubiak; Evan W Miller; Roger Y Tsien
Journal: J Am Chem Soc Date: 2015-01-29 Impact factor: 15.419

5. DNAzyme Based Amplified Biosensor on Ultrasensitive Fluorescence Detection of Pb (II) Ions from Aqueous System.

Authors: A Ravikumar; P Panneerselvam; K Radhakrishnan; Norhashimah Morad; C D Anuradha; S Sivanesan
Journal: J Fluoresc Date: 2017-08-17 Impact factor: 2.217

6. Reusable resistive aptasensor for Pb(II) based on the Pb(II)-induced despiralization of a DNA duplex and formation of a G-quadruplex.

Authors: Hui Wang; Yang Liu; Gang Liu
Journal: Mikrochim Acta Date: 2018-01-29 Impact factor: 5.833

A selective fluorescent sensor for detecting lead in living cells.

1. Colorimetric Determination of Pb²⁺ in Perfect Aqueous Solution Using Carminic Acid as a Selective Chemosensor.

Review 2. Fluorescent sensors for measuring metal ions in living systems.

3. Carbamodithioate-based dual functional fluorescent probe for Hg(2+) and S(2-).

4. Improved PeT molecules for optically sensing voltage in neurons.

5. DNAzyme Based Amplified Biosensor on Ultrasensitive Fluorescence Detection of Pb (II) Ions from Aqueous System.

6. Reusable resistive aptasensor for Pb(II) based on the Pb(II)-induced despiralization of a DNA duplex and formation of a G-quadruplex.

7. Near-Infrared Fluorescent Probe for Sensitive Detection of Pb(II) Ions in Living Cells.

8. Water-Soluble Osmium Complexes Suitable for use in Luminescence-Based, Hydrogel-Supported Sensors.

9. A DNAzyme-gold nanoparticle probe for uranyl ion in living cells.

10. One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.