| Literature DB >> 16848277 |
Africa Holguín1, Eva Ramirez de Arellano, Pablo Rivas, Vincent Soriano.
Abstract
The impact of HIV-1 subtype on clinical outcome following exposure to antiretroviral therapy is currently not well known. Natural polymorphisms are often present in HIV-1 non-B subtypes at positions known to be associated with drug resistance in clade B viruses. These changes might influence the emergence of drug-resistant viruses, modifying drug susceptibility and/or the virus replicative capacity. Moreover, different pathways may lead to drug resistance according to HIV-1 clade. Finally, the influence of subtype on the performance of phenotypic assays and in the interpretation of algorithms for genotypic resistance is currently a matter of debate. All these aspects explain why the response to antiretroviral therapy might vary in subjects infected with different HIV-1 clades.Entities:
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Year: 2006 PMID: 16848277
Source DB: PubMed Journal: AIDS Rev ISSN: 1139-6121 Impact factor: 2.500