BACKGROUND: Adhesions due to the reactions caused by the grafts used in primary vascular operations can lead to various problems when a secondary operation is necessary. These problems include bleeding, injuries to neighboring organs, and complications occurring due to a prolonged operation. We investigated the effects of sirolimus, which has antiproliferative features, on vascular adhesions. METHODS: The abdominal aorta of rats was explored and abrasions applied. Following the fixation of a polytetrafluoroethylene (PTFE) graft on the abdominal aorta, sirolimus (rapamycin) is applied (in powdered form) onto the grafts of the study group. Eight weeks later a laparotomy was repeated and any adhesions were evaluated. RESULTS: In the study group the adhesions were determined to be fewer in number and milder in severity. Severe cases of adhesion were determined in the control group. CONCLUSIONS: Therefore, sirolimus applied around the prosthesis in vascular operations was determined to be effective at preventing possible adhesions.
BACKGROUND: Adhesions due to the reactions caused by the grafts used in primary vascular operations can lead to various problems when a secondary operation is necessary. These problems include bleeding, injuries to neighboring organs, and complications occurring due to a prolonged operation. We investigated the effects of sirolimus, which has antiproliferative features, on vascular adhesions. METHODS: The abdominal aorta of rats was explored and abrasions applied. Following the fixation of a polytetrafluoroethylene (PTFE) graft on the abdominal aorta, sirolimus (rapamycin) is applied (in powdered form) onto the grafts of the study group. Eight weeks later a laparotomy was repeated and any adhesions were evaluated. RESULTS: In the study group the adhesions were determined to be fewer in number and milder in severity. Severe cases of adhesion were determined in the control group. CONCLUSIONS: Therefore, sirolimus applied around the prosthesis in vascular operations was determined to be effective at preventing possible adhesions.
Authors: C Belluco; F Meggiolaro; D Pressato; A Pavesio; E Bigon; M Donà; M Forlin; D Nitti; M Lise Journal: J Surg Res Date: 2001-10 Impact factor: 2.192
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