Yu Sakai1. 1. Department of Pathology, Japan Self Defense Forces Sapporo General Hospital, 12-1-32 Hiragishi 1 Jo, Sapporo, Hokkaido 062-0931, Japan. ZWQ04043@nifty.ne.jp
Abstract
CASE: A unique case of granulosa cell tumor arising in a müllerian cyst of the broad ligament in a 57-year-old woman is presented. The surgically resected unilocular cyst, measuring 9.5 x 9.5 x 6.5 cm3, situated within the right broad ligament. The inner surface of the cyst was lined by a single layer of ciliated columnar cells. Solid cell sheath of the spindled cells were demonstrated in this cystic wall. Immunohistochemically, these spindled cells were diffusely positive for cytokeratin 7, AE1/AE3, vimentin, smooth muscle actin, calretinin and weakly positive for inhibin, but negative for cytokeratin 20, epithelial membrane antigen and CD10. CONCLUSION: Immunohistochemical findings suggested solid cell sheath surrounding the cyst was granulosa cell tumor. Granulosa cell tumor coexisted with müllerian cyst in the current case was recognized a unique histological feature.
CASE: A unique case of granulosa cell tumor arising in a müllerian cyst of the broad ligament in a 57-year-old woman is presented. The surgically resected unilocular cyst, measuring 9.5 x 9.5 x 6.5 cm3, situated within the right broad ligament. The inner surface of the cyst was lined by a single layer of ciliated columnar cells. Solid cell sheath of the spindled cells were demonstrated in this cystic wall. Immunohistochemically, these spindled cells were diffusely positive for cytokeratin 7, AE1/AE3, vimentin, smooth muscle actin, calretinin and weakly positive for inhibin, but negative for cytokeratin 20, epithelial membrane antigen and CD10. CONCLUSION: Immunohistochemical findings suggested solid cell sheath surrounding the cyst was granulosa cell tumor. Granulosa cell tumor coexisted with müllerian cyst in the current case was recognized a unique histological feature.