Literature DB >> 16847556

A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin.

Zuzanna Drulis-Kawa1, Jerzy Gubernator, Agata Dorotkiewicz-Jach, Włodzimierz Doroszkiewicz, Arkadiusz Kozubek.   

Abstract

The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those of the free drug.

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Year:  2006        PMID： 16847556      PMCID： PMC6472838          DOI： 10.2478/s11658-006-0030-6

Source DB:  PubMed          Journal:  Cell Mol Biol Lett        ISSN： 1425-8153            Impact factor:   5.787


  5 in total

1.  Development of a bioorthogonal fluorescence-based assay for assessing drug uptake and delivery in bacteria.

Authors:  Jocelyn M F Ooi; Jessica M Fairhall; Benjamin Spangler; Daniel J W Chong; Brian Y Feng; Allan B Gamble; Sarah Hook
Journal:  RSC Adv       Date:  2022-05-23       Impact factor: 4.036

2.  Improvement of the pharmacokinetics and in vivo antibacterial efficacy of a novel type IIa topoisomerase inhibitor by formulation in liposomes.

Authors:  Adam B Shapiro; Joseph Newman; Kosalaram Goteti; Marie-Eve Beaudoin; Rane Harrison; Sussie Hopkins; Nikunj Agrawal; Olga Rivin
Journal:  Antimicrob Agents Chemother       Date:  2013-07-22       Impact factor: 5.191

3.  Facile Biofilm Penetration of Cationic Liposomes Loaded with DNase I/Proteinase K to Eradicate Cutibacterium acnes for Treating Cutaneous and Catheter Infections.

Authors:  Jia-You Fang; Wei-Ling Chou; Chwan-Fwu Lin; Calvin T Sung; Ahmed Alalaiwe; Shih-Chun Yang
Journal:  Int J Nanomedicine       Date:  2021-12-16

4.  Efficacy of neutral and negatively charged liposome-loaded gentamicin on planktonic bacteria and biofilm communities.

Authors:  Moayad Alhariri; Majed A Majrashi; Ali H Bahkali; Faisal S Almajed; Ali O Azghani; Mohammad A Khiyami; Essam J Alyamani; Sameera M Aljohani; Majed A Halwani
Journal:  Int J Nanomedicine       Date:  2017-09-18

5.  Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor.

Authors:  Menka Drost; Eleonora Diamanti; Kathrin Fuhrmann; Adriely Goes; Atanaz Shams; Jörg Haupenthal; Marcus Koch; Anna K H Hirsch; Gregor Fuhrmann
Journal:  Pharmaceutics       Date:  2021-12-21       Impact factor: 6.321
  5 in total

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