Literature DB >> 16847410

Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection.

Galit Alter1, Todd J Suscovich, Marianna Kleyman, Nickolas Teigen, Hendrik Streeck, M Tauheed Zaman, Angela Meier, Marcus Altfeld.   

Abstract

Natural killer (NK) cells are critical for the first-line defense in infection. Treated viremic HIV-1 infection is associated with the expansion of an anergic subset of CD3-CD56-CD16+ NK cells unable to respond to stimulation with MHC-devoid target cells or with mitogens. These CD3-CD56-CD16+ NK cells expressed SHIP-1 and had significantly reduced perforin levels. This observation suggests a mechanism for the reduced functional activity of CD3-CD56-CD16+ NK cells in chronic HIV-1 infection.

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Year:  2006        PMID： 16847410     DOI： 10.1097/01.aids.0000237371.31315.48

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  17 in total

Review 1.  Natural killer cells in immunodefense against infective agents.

Authors:  Nicolas Zucchini; Karine Crozat; Thomas Baranek; Scott H Robbins; Marcus Altfeld; Marc Dalod
Journal:  Expert Rev Anti Infect Ther       Date:  2008-12       Impact factor: 5.091

2.  Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults.

Authors:  Ambrose H W Wong; Katie Williams; Sharon Reddy; Douglas Wilson; Janet Giddy; Galit Alter; Musie Ghebremichael; Mary N Carrington; Thumbi Ndung'u; Bruce D Walker; Marcus Altfeld; William H Carr
Journal:  AIDS Res Hum Retroviruses       Date:  2010-04       Impact factor: 2.205

3.  Non-linear multidimensional flow cytometry analyses delineate NK cell phenotypes in normal and HIV-infected chimpanzees.

Authors:  Cordelia Manickam; Haiying Li; Spandan V Shah; Kyle Kroll; R Keith Reeves
Journal:  Int Immunol       Date:  2019-03-05       Impact factor: 4.823

4.  A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- or SIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays.

Authors:  Michael D Alpert; Lisa N Heyer; David E J Williams; Jackson D Harvey; Thomas Greenough; Maria Allhorn; David T Evans
Journal:  J Virol       Date:  2012-08-29       Impact factor: 5.103

Review 5.  Here today--not gone tomorrow: roles for activating receptors in sustaining NK cells during viral infections.

Authors:  Seung-Hwan Lee; Christine A Biron
Journal:  Eur J Immunol       Date:  2010-04       Impact factor: 5.532

6.  Natural-killer cell-derived cytolytic molecules in HIV-associated pulmonary tuberculosis-role of exogenous interleukins.

Authors:  P V Ramana Rao; S Ramanavelan; S Rajasekaran; Alamelu Raja
Journal:  J Clin Immunol       Date:  2010-03-13       Impact factor: 8.317

7.  Infection with Vpr-positive human immunodeficiency virus type 1 impairs NK cell function indirectly through cytokine dysregulation of infected target cells.

Authors:  Biswanath Majumder; Narasimhan J Venkatachari; Shaylee O'Leary; Velpandi Ayyavoo
Journal:  J Virol       Date:  2008-04-16       Impact factor: 5.103

8.  Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.

Authors:  Wassim M Ballan; Bien-Aimee N Vu; Brian R Long; Christopher P Loo; Jakob Michaëlsson; Jason D Barbour; Lewis L Lanier; Andrew A Wiznia; Jacobo Abadi; Glenn J Fennelly; Michael G Rosenberg; Douglas F Nixon
Journal:  J Immunol       Date:  2007-09-01       Impact factor: 5.422

9.  The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life.

Authors:  Jennifer A Slyker; Barbara Lohman-Payne; Grace C John-Stewart; Tao Dong; Dorothy Mbori-Ngacha; Kenneth Tapia; Ann Atzberger; Stephen Taylor; Sarah L Rowland-Jones; Catherine A Blish
Journal:  Front Immunol       Date:  2012-12-31       Impact factor: 7.561

10.  In vivo assessment of natural killer cell responses during chronic feline immunodeficiency virus infection.

Authors:  Rita D Simões; Kristina E Howard; Gregg A Dean
Journal:  PLoS One       Date:  2012-05-31       Impact factor: 3.240
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