| Literature DB >> 16845384 |
Lucas Sosa1, Sebastian Dupraz, Lisandro Laurino, Flavia Bollati, Mariano Bisbal, Alfredo Cáceres, Karl H Pfenninger, Santiago Quiroga.
Abstract
How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1) receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.Entities:
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Year: 2006 PMID： 16845384 DOI： 10.1038/nn1742
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884