BACKGROUND AND AIMS: Plasma polyunsaturated fatty acid profile in patients with inflammatory bowel disease is abnormal. We aimed to assess the mucosal fatty acid pattern in patients with ulcerative colitis and Crohn's disease, and in rats with trinitrobenzene-sulfonic acid (TNB) induced colitis. METHODS: Fatty acids were measured in colonic mucosa of patients with ulcerative colitis (n = 30), Crohn's disease (n = 21), and healthy controls (n = 13). Likewise, they were assessed in the colonic mucosa of rats with TNB- and sham-colitis. RESULTS: There was an increase of the end-products (C22:5n3, C22:6n3, C20:4n6, C22:5n6) and a decrease of the precursors (C18:3n3, C18:2n6) of both n3 and n6 polyunsaturated fatty acids in the mucosa of active ulcerative colitis and TNB-colitis. Also, high values of saturated (C16:0, C18:0) and low values of monounsaturated fatty acids (C18:1n9) were observed. Furthermore, the mucosa of active Crohn's disease showed substantial changes in saturated, monounsaturated and essential fatty acids, but not in polyunsaturated fatty acids. Mucosa of patients with inactive disease showed intermediate fatty acid values between the mucosa of active patients and healthy controls. CONCLUSIONS: Colonic inflammation causes a characteristic modification of the mucosal fatty acid profile which appears to be common to different aetiologies and seems to be related to the degree of inflammation.
BACKGROUND AND AIMS: Plasma polyunsaturated fatty acid profile in patients with inflammatory bowel disease is abnormal. We aimed to assess the mucosal fatty acid pattern in patients with ulcerative colitis and Crohn's disease, and in rats with trinitrobenzene-sulfonic acid (TNB) induced colitis. METHODS:Fatty acids were measured in colonic mucosa of patients with ulcerative colitis (n = 30), Crohn's disease (n = 21), and healthy controls (n = 13). Likewise, they were assessed in the colonic mucosa of rats with TNB- and sham-colitis. RESULTS: There was an increase of the end-products (C22:5n3, C22:6n3, C20:4n6, C22:5n6) and a decrease of the precursors (C18:3n3, C18:2n6) of both n3 and n6 polyunsaturated fatty acids in the mucosa of active ulcerative colitis and TNB-colitis. Also, high values of saturated (C16:0, C18:0) and low values of monounsaturated fatty acids (C18:1n9) were observed. Furthermore, the mucosa of active Crohn's disease showed substantial changes in saturated, monounsaturated and essential fatty acids, but not in polyunsaturated fatty acids. Mucosa of patients with inactive disease showed intermediate fatty acid values between the mucosa of active patients and healthy controls. CONCLUSIONS:Colonic inflammation causes a characteristic modification of the mucosal fatty acid profile which appears to be common to different aetiologies and seems to be related to the degree of inflammation.
Authors: Janet Jansson; Ben Willing; Marianna Lucio; Ages Fekete; Johan Dicksved; Jonas Halfvarson; Curt Tysk; Philippe Schmitt-Kopplin Journal: PLoS One Date: 2009-07-28 Impact factor: 3.240
Authors: J Schwarz; M Vecka; F Stožický; R Pomahačová; B Staňková; E Tvrzická; M Kreslová; R Zahálková; J Sýkora Journal: Physiol Res Date: 2021-09-10 Impact factor: 1.881
Authors: Dawn M Wiese; Sara N Horst; Caroline T Brown; Margaret M Allaman; Mallary E Hodges; James C Slaughter; Jennifer P Druce; Dawn B Beaulieu; David A Schwartz; Keith T Wilson; Lori A Coburn Journal: PLoS One Date: 2016-05-26 Impact factor: 3.240
Authors: Thomas Lee; Thomas Clavel; Kirill Smirnov; Annemarie Schmidt; Ilias Lagkouvardos; Alesia Walker; Marianna Lucio; Bernhard Michalke; Philippe Schmitt-Kopplin; Richard Fedorak; Dirk Haller Journal: Gut Date: 2016-02-04 Impact factor: 23.059