Literature DB >> 16844350

bla(OXA-51)-type beta-lactamase genes are ubiquitous and vary within a strain in Acinetobacter baumannii.

Andrea Karina Merkier1, Daniela Centrón.   

Abstract

We investigated the spread of bla(OXA-51)-type beta-lactamase genes in 200 Acinetobacter spp. clinical strains isolated in Argentina from 1982 to 2005. bla(OXA-51)-type genes were present in all Acinetobacter baumannii isolates tested (n=194), whereas they were not detected in two Acinetobacter haemolyticus, two genomic species 10 or two Acinetobacter lwoffii isolates. The bla(OXA-51)-type alleles varied within a strain and were found in six different A. baumannii pulsed-field gel electrophoresis clones that were susceptible or resistant to imipenem, suggesting a controversial role in imipenem resistance. Our findings agree with previous reports showing that bla(OXA-51)-type genes are naturally harboured by A. baumannii isolates from various geographical origins and support the presence of a direct reservoir of beta-lactam resistance genes within the nosocomial environment.

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Year:  2006        PMID： 16844350     DOI： 10.1016/j.ijantimicag.2006.03.023

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  23 in total

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Authors:  María Soledad Ramírez; Andrea Karina Merkier; Marisa Almuzara; Carlos Vay; Daniela Centrón
Journal:  Antimicrob Agents Chemother       Date:  2010-08-02       Impact factor: 5.191

2.  Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.

Authors:  Stéphane Corvec; Laurent Poirel; Thierry Naas; Henri Drugeon; Patrice Nordmann
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3.  The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity.

Authors:  Cynthia M June; Taylor J Muckenthaler; Emma C Schroder; Zachary L Klamer; Zdzislaw Wawrzak; Rachel A Powers; Agnieszka Szarecka; David A Leonard
Journal:  Protein Sci       Date:  2016-09-26       Impact factor: 6.725

4.  Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.

Authors:  Maria Soledad Ramirez; Mark D Adams; Robert A Bonomo; Daniela Centrón; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

5.  Identification of blaOXA-₅₁-like, blaOXA-₅₈, blaDIM-₁, and blaVIM carbapenemase genes in hospital Enterobacteriaceae isolates from Sierra Leone.

Authors:  Tomasz A Leski; Umaru Bangura; David H Jimmy; Rashid Ansumana; Stephen E Lizewski; Robert W Li; David A Stenger; Chris R Taitt; Gary J Vora
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6.  Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems.

Authors:  Emma C Schroder; Zachary L Klamer; Aysegul Saral; Kyle A Sugg; Cynthia M June; Troy Wymore; Agnieszka Szarecka; David A Leonard
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

7.  Clonal spread of carbapenem resistant Acinetobacter baumannii ST92 in a Chinese Hospital during a 6-year period.

Authors:  Lei Huang; Liying Sun; Yan Yan
Journal:  J Microbiol       Date:  2013-03-02       Impact factor: 3.422

8.  Distribution of allelic variants of the chromosomal gene bla OXA-114-like in Achromobacter xylosoxidans clinical isolates.

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Journal:  Curr Microbiol       Date:  2013-06-15       Impact factor: 2.188

9.  An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii.

Authors:  Wensi S Hu; Shu-Man Yao; Chang-Phone Fung; Yi-Ping Hsieh; Chang-Pan Liu; Jing-Fang Lin
Journal:  Antimicrob Agents Chemother       Date:  2007-08-27       Impact factor: 5.191

10.  Outbreaks of imipenem resistant Acinetobacter baumannii producing OXA-23 beta-lactamase in a tertiary care hospital in Korea.

Authors:  Hee Young Yang; Hee Joo Lee; Jin Tae Suh; Kyeong Min Lee
Journal:  Yonsei Med J       Date:  2009-12-18       Impact factor: 2.759
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