| Literature DB >> 16844139 |
Lisa M Graham1, S Vicky Tsoni, Janet A Willment, David L Williams, Philip R Taylor, Siamon Gordon, Kevin Dennehy, Gordon D Brown.
Abstract
Beta-glucans are structural components of fungal cell walls which are involved in the immune recognition of fungal pathogens and possess beneficial immunomodulatory activities in isolated form. Here we have developed a soluble chimeric form of the major mammalian beta-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble beta-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays.Entities:
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Year: 2006 PMID: 16844139 DOI: 10.1016/j.jim.2006.05.013
Source DB: PubMed Journal: J Immunol Methods ISSN: 0022-1759 Impact factor: 2.303