| Literature DB >> 16844116 |
Toru Yamada1, Muneharu Maruyama, Tadashi Fujita, Koutarou Miyabayashi, Chie Shinoda, Yukio Kawagishi, Takashi Fujishita, Ryuji Hayashi, Toshiro Miwa, Nobuki Arai, Shoko Matsui, Eiji Sugiyama, Masashi Kobayashi.
Abstract
Ionizing radiation (IR) is known to upregulate cell surface Fas through p53 activation in various cells. However, the signaling pathway intermediating between p53 activation and cell surface Fas upregulation remains to be elucidated. Recently, Fas-associated phosphatase-1 (FAP-1) has been reported to associate with Fas and inhibit cell surface Fas expression. We evaluated the expression of FAP-1 mRNA following IR in A549 cells. Ionizing radiation inhibited the expression of FAP-1 mRNA. Pretreatment with p53 inhibitor pifithrin alpha cancelled the IR-induced downregulation of FAP-1 mRNA. These results suggest that IR-induced p53 activation may upregulate cell surface Fas via the down-modulation of FAP-1.Entities:
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Year: 2006 PMID： 16844116 DOI： 10.1016/j.febslet.2006.07.003
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124