| Literature DB >> 16844078 |
Fuminori Umenishi1, Takefumi Narikiyo, Alain Vandewalle, Robert W Schrier.
Abstract
The regulation of AVP-induced AQP2 expression was investigated in the present study. AVP administration induced AQP2 expression in a dose-dependent manner in association with an increase in intracellular cAMP concentration. PKA activity was stimulated by AVP but PKA inhibitors did not block the upregulation of AQP2 expression. However, AVP also activated both ERK and CREB pathways, and ERK inhibitor attenuated the upregulation of AQP2 expression. These results therefore indicate that the effect of AVP stimulation to upregulate AQP2 expression involves a PKA-independent pathway.Entities:
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Year: 2006 PMID： 16844078 DOI： 10.1016/j.bbamem.2006.06.001
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002