BACKGROUND: In January 1999 a new kidney allocation program was launched by the Eurotransplant Foundation, the 'Eurotransplant Senior Program' (ESP). Cadaveric donors above the age of 65 yr are allocated to kidney transplant recipients of the same age group. METHODS: Using a single-center database, 91 patients who underwent first renal transplantation at the age of 65 yr and older in the years 1999-2002 were identified. Fifty-six patients were transplanted through ESP allocation (study group) and 35 patients (control group) via normal Eurotransplant Kidney Allocation System (ETKAS) procedure. RESULTS: Age, sex and comorbid conditions did not differ by group. The rate of acute rejection episodes, primary non-function, delayed graft function, perioperative mortality did not differ by group. Serum creatinine was significantly lower in the ETKAS group (1.3 vs. 1.9 mg/dL; p=0.015) from six months after the transplantation on. Overall graft survival at six yr was 56% in the ETKAS group and 52% in the ESP group. With 73% in the ETKAS group and 71% in the ESP group, cumulative patient survival according to the Kaplan-Meier estimation was not statistically different at five yr. CONCLUSIONS: We did not find a relevant difference in the outcome between young and old kidney transplants in old recipients after this long observation period.
BACKGROUND: In January 1999 a new kidney allocation program was launched by the Eurotransplant Foundation, the 'Eurotransplant Senior Program' (ESP). Cadaveric donors above the age of 65 yr are allocated to kidney transplant recipients of the same age group. METHODS: Using a single-center database, 91 patients who underwent first renal transplantation at the age of 65 yr and older in the years 1999-2002 were identified. Fifty-six patients were transplanted through ESP allocation (study group) and 35 patients (control group) via normal Eurotransplant Kidney Allocation System (ETKAS) procedure. RESULTS: Age, sex and comorbid conditions did not differ by group. The rate of acute rejection episodes, primary non-function, delayed graft function, perioperative mortality did not differ by group. Serum creatinine was significantly lower in the ETKAS group (1.3 vs. 1.9 mg/dL; p=0.015) from six months after the transplantation on. Overall graft survival at six yr was 56% in the ETKAS group and 52% in the ESP group. With 73% in the ETKAS group and 71% in the ESP group, cumulative patient survival according to the Kaplan-Meier estimation was not statistically different at five yr. CONCLUSIONS: We did not find a relevant difference in the outcome between young and old kidney transplants in old recipients after this long observation period.
Authors: Javier Barba; Juan Javier Zudaire; José Enrique Robles; David Rosell; José María Berian; Ignacio Pascual Journal: World J Urol Date: 2013-08 Impact factor: 4.226
Authors: Markus Giessing; T Florian Fuller; Frank Friedersdorff; Serdar Deger; Andreas Wille; Hans-Hellmut Neumayer; Danilo Schmidt; Klemens Budde; Lutz Liefeldt Journal: J Am Soc Nephrol Date: 2008-12-10 Impact factor: 10.121
Authors: Andrea Proneth; Andreas A Schnitzbauer; Florian Zeman; Johanna R Foerster; Ines Holub; Helmut Arbogast; Wolf O Bechstein; Thomas Becker; Carsten Dietz; Markus Guba; Michael Heise; Sven Jonas; Stephan Kersting; Jürgen Klempnauer; Steffen Manekeller; Volker Müller; Silvio Nadalin; Björn Nashan; Andreas Pascher; Falk Rauchfuss; Michael A Ströhlein; Peter Schemmer; Peter Schenker; Stefan Thorban; Thomas Vogel; Axel O Rahmel; Richard Viebahn; Bernhard Banas; Edward K Geissler; Hans J Schlitt; Stefan A Farkas Journal: Transplant Res Date: 2013-07-01