| Literature DB >> 16842499 |
J P Mothet1, E Rouaud, P-M Sinet, B Potier, A Jouvenceau, P Dutar, C Videau, J Epelbaum, J-M Billard.
Abstract
Age-associated deficits in learning and memory are closely correlated with impairments of synaptic plasticity. Analysis of N-methyl-D-aspartate receptor (NMDAr)-dependent long-term potentiation (LTP) in CA1 hippocampal slices indicates that the glial-derived neuromodulator D-serine is required for the induction of synaptic plasticity. During aging, the content of D-serine and the expression of its synthesizing enzyme serine racemase are significantly decreased in the hippocampus. Impaired LTP and NMDAr-mediated synaptic potentials in old rats are rescued by exogenous D-serine. These results highlight the critical role of glial cells and presumably astrocytes, through the availability of D-serine, in the deficits of synaptic mechanisms of learning and memory that occur in the course of aging.Entities:
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Year: 2006 PMID： 16842499 DOI： 10.1111/j.1474-9726.2006.00216.x
Source DB: PubMed Journal: Aging Cell ISSN： 1474-9718 Impact factor: 9.304