Literature DB >> 16842124

Fused 1,4-dihydropyridines as potential calcium modulatory compounds.

Cihat Safak1, Rahime Simsek.   

Abstract

1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium antagonistic activity. Fused 1,4-dihydropyridines (DHPs) have also exhibit calcium modulatory activities. In this article, we emphasize calcium channels and fused 1,4-DHP derivatives affecting calcium channels. In addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.

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Year:  2006        PMID： 16842124     DOI： 10.2174/138955706777698606

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  14 in total

1.  Application of electron conformational-genetic algorithm approach to 1,4-dihydropyridines as calcium channel antagonists: pharmacophore identification and bioactivity prediction.

Authors:  Nazmiye Geçen; Emin Sarıpınar; Ersin Yanmaz; Kader Sahin
Journal:  J Mol Model       Date:  2011-03-31       Impact factor: 1.810

Review 2.  Synthesis of Biologically Active Molecules through Multicomponent Reactions.

Authors:  Daniel Insuasty; Juan Castillo; Diana Becerra; Hugo Rojas; Rodrigo Abonia
Journal:  Molecules       Date:  2020-01-24       Impact factor: 4.411

3.  RuIII@CMC/Fe3O4 hybrid: an efficient, magnetic, retrievable, self-organized nanocatalyst for green synthesis of pyranopyrazole and polyhydroquinoline derivatives.

Authors:  Yang Chen; Zhuan Zhang; Wei Jiang; Mingjuan Zhang; Yiqun Li
Journal:  Mol Divers       Date:  2018-10-29       Impact factor: 2.943

4.  Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

Authors:  Dennis Schade; Marion Lanier; Erik Willems; Karl Okolotowicz; Paul Bushway; Christine Wahlquist; Cynthia Gilley; Mark Mercola; John R Cashman
Journal:  J Med Chem       Date:  2012-11-06       Impact factor: 7.446

5.  Synthesis of styryl-linked fused dihydropyridines by catalyst-free multicomponent reactions.

Authors:  Rahul Yadav; Tasneem Parvin; Anoop Kumar Panday; Lokman H Choudhury
Journal:  Mol Divers       Date:  2021-04-16       Impact factor: 2.943

6.  Antihypertensive effects of new dihydropyridine derivatives on phenylephrine-raised blood pressure in rats.

Authors:  Sara Rowghani Haghighi Fard; Ramin Miri; Ali Akbar Nekooeian
Journal:  Res Pharm Sci       Date:  2016-12

7.  An umpolung approach to the hydroboration of pyridines: a novel and efficient synthesis of N-H 1,4-dihydropyridines.

Authors:  Huan Yang; Li Zhang; Fei-Yu Zhou; Lei Jiao
Journal:  Chem Sci       Date:  2019-12-03       Impact factor: 9.825

8.  Ethyl 2,7,7-trimethyl-4-(1-methyl-1H-indol-3-yl)-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

Authors:  Sema Oztürk Yildirim; Ray J Butcher; Miyase Gözde Gündüz; Ahmed El-Khouly; Rahime Simşek; Cihat Safak
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-12-08

9.  Synthesis of Novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] Dihydropyridines and Studying their Effects on Rat Blood Pressure.

Authors:  Seyed Ahmad Mohajeri; Hossein Hosseinzadeh; Sara Salami; Vahidehsadat Motamedshariaty; Mahmoud Seifi; Farzin Hadizadeh
Journal:  Iran J Basic Med Sci       Date:  2011-09       Impact factor: 2.699

10.  Ethyl 4-(5-bromo-1H-indol-3-yl)-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.

Authors:  Miyase Gözde Gündüz; Ray J Butcher; Sema Oztürk Yildirim; Ahmed El-Khouly; Cihat Safak; Rahime Simşek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-11-24
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