Literature DB >> 16841064

Drugging the PI3 kinome.

Paul Workman, Paul A Clarke, Sandrine Guillard, Florence I Raynaud.   

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Year:  2006        PMID： 16841064     DOI： 10.1038/nbt0706-794

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  22 in total

Review 1.  Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.

Authors:  Margrith E Mattmann; Sydney L Stoops; Craig W Lindsley
Journal:  Expert Opin Ther Pat       Date:  2011-06-02       Impact factor: 6.674

Review 2.  Drugging the PI3 kinome: from chemical tools to drugs in the clinic.

Authors:  Paul Workman; Paul A Clarke; Florence I Raynaud; Rob L M van Montfort
Journal:  Cancer Res       Date:  2010-02-23       Impact factor: 12.701

3.  Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior.

Authors:  Andre Fischer; Marko Radulovic; Christina Schrick; Farahnaz Sananbenesi; Jasminka Godovac-Zimmermann; Jelena Radulovic
Journal:  Neurobiol Learn Mem       Date:  2006-09-18       Impact factor: 2.877

Review 4.  Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase.

Authors:  J S Oak; M P Matheu; I Parker; M D Cahalan; D A Fruman
Journal:  Biochem Soc Trans       Date:  2007-11       Impact factor: 5.407

5.  In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

Authors:  Sylvestor A Moses; M Ahad Ali; Song Zuohe; Lei Du-Cuny; Li Li Zhou; Robert Lemos; Nathan Ihle; A Geoffrey Skillman; Shuxing Zhang; Eugene A Mash; Garth Powis; Emmanuelle J Meuillet
Journal:  Cancer Res       Date:  2009-06-02       Impact factor: 12.701

6.  Discovery of a novel class of AKT pleckstrin homology domain inhibitors.

Authors:  Daruka Mahadevan; Garth Powis; Eugene A Mash; Benjamin George; Vijay M Gokhale; Shuxing Zhang; Kishore Shakalya; Lei Du-Cuny; Margareta Berggren; M Ahad Ali; Umasish Jana; Nathan Ihle; Sylvestor Moses; Chloe Franklin; Satya Narayan; Nikhil Shirahatti; Emmanuelle J Meuillet
Journal:  Mol Cancer Ther       Date:  2008-09       Impact factor: 6.261

7.  Single-cell analysis of phosphoinositide 3-kinase and phosphatase and tensin homolog activation.

Authors:  Dechen Jiang; Christopher Eldridge Sims; Nancy Lynn Allbritton
Journal:  Faraday Discuss       Date:  2011       Impact factor: 4.008

8.  Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.

Authors:  Myriam M Chaumeil; Tomoko Ozawa; IlWoo Park; Kristen Scott; C David James; Sarah J Nelson; Sabrina M Ronen
Journal:  Neuroimage       Date:  2011-07-23       Impact factor: 6.556

9.  Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases.

Authors:  Teresa G Granda; David Cebrián; Sonia Martínez; Patricia Villanueva Anguita; Estela Casas López; Wolfgang Link; Teresa Merino; Joaquín Pastor; Beatriz G Serelde; Sandra Peregrina; Irene Palacios; Maria Isabel Albarran; Antonio Cebriá; Milagros Lorenzo; Patricia Alonso; Jesús Fominaya; Ana Rodríguez López; James R Bischoff
Journal:  Invest New Drugs       Date:  2012-05-24       Impact factor: 3.850

10.  Elucidation of binding mode and three dimensional quantitative structure-activity relationship studies of a novel series of protein kinase B/Akt inhibitors.

Authors:  M Muddassar; F A Pasha; M M Neaz; Y Saleem; S J Cho
Journal:  J Mol Model       Date:  2008-11-29       Impact factor: 1.810
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