BACKGROUND: The purpose of this study was to determine the influence of changes in cardiac size on total lung volume in patients with chronic heart failure compared to control subjects. METHODS: Forty-four patients and age-, gender-, and height-matched control participants were recruited. All participants underwent posteroanterior and lateral chest radiography for volumetric estimations of the total thoracic cavity (TTC), diaphragm, heart, and lungs. To assess the relationship between chronic heart failure severity and cardiac enlargement, patients with chronic heart failure were classified into groups based on New York Heart Association class, as follows: class I and II, n = 26 (group A); class III and IV, n = 18 (group B). RESULTS: There was no difference between the groups for TTC volume (TTCV) [p = 0.56]. Cardiac volumes were significantly different between all groups for both the absolute volumes (p < 0.001) were calculated as a percentage of TTCV (p < 0.001), with the largest cardiac volumes in group B (twice the volume of healthy control subjects). When expressed as a percentage of TTCV, there also was a clear reduction in lung volumes as a function of disease severity (p < 0.001). CONCLUSIONS: The present study demonstrates a close relationship between the severity of heart failure and cardiac size. These changes in cardiac size within a closed thoracic cavity may pose significant constraints on the lungs, resulting in reductions in lung volumes that likely play a major role in the restrictive breathing patterns often reported in patients with chronic heart failure.
BACKGROUND: The purpose of this study was to determine the influence of changes in cardiac size on total lung volume in patients with chronic heart failure compared to control subjects. METHODS: Forty-four patients and age-, gender-, and height-matched control participants were recruited. All participants underwent posteroanterior and lateral chest radiography for volumetric estimations of the total thoracic cavity (TTC), diaphragm, heart, and lungs. To assess the relationship between chronic heart failure severity and cardiac enlargement, patients with chronic heart failure were classified into groups based on New York Heart Association class, as follows: class I and II, n = 26 (group A); class III and IV, n = 18 (group B). RESULTS: There was no difference between the groups for TTC volume (TTCV) [p = 0.56]. Cardiac volumes were significantly different between all groups for both the absolute volumes (p < 0.001) were calculated as a percentage of TTCV (p < 0.001), with the largest cardiac volumes in group B (twice the volume of healthy control subjects). When expressed as a percentage of TTCV, there also was a clear reduction in lung volumes as a function of disease severity (p < 0.001). CONCLUSIONS: The present study demonstrates a close relationship between the severity of heart failure and cardiac size. These changes in cardiac size within a closed thoracic cavity may pose significant constraints on the lungs, resulting in reductions in lung volumes that likely play a major role in the restrictive breathing patterns often reported in patients with chronic heart failure.
Authors: Thomas P Olson; Michael J Joyner; Niki M Dietz; John H Eisenach; Timothy B Curry; Bruce D Johnson Journal: J Physiol Date: 2010-05-10 Impact factor: 5.182
Authors: Thomas P Olson; Robert P Frantz; Eric M Snyder; Kathy A O'Malley; Kenneth C Beck; Bruce D Johnson Journal: Am Heart J Date: 2007-01 Impact factor: 4.749
Authors: Sunil K Agarwal; Gerardo Heiss; R Graham Barr; Patricia P Chang; Laura R Loehr; Lloyd E Chambless; Eyal Shahar; Dalane W Kitzman; Wayne D Rosamond Journal: Eur J Heart Fail Date: 2012-02-25 Impact factor: 15.534
Authors: Ivan Cundrle; Bruce D Johnson; Virend K Somers; Christopher G Scott; Robert F Rea; Lyle J Olson Journal: Am J Cardiol Date: 2013-06-05 Impact factor: 2.778