Literature DB >> 16839864

Cytochrome P450 epoxygenase CYP2J2 and the risk of coronary artery disease.

Martin Spiecker1, Jamesk Liao.   

Abstract

Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16839864     DOI： 10.1016/j.tcm.2006.04.001

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  13 in total

1.  Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes.

Authors:  Eric A Evangelista; Rüdiger Kaspera; Nahush A Mokadam; J P Jones; Rheem A Totah
Journal:  Drug Metab Dispos       Date:  2013-09-10       Impact factor: 3.922

2.  CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo.

Authors:  Jinge G Zhu; Justin T Ochalek; Martin Kaufmann; Glenville Jones; Hector F Deluca
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-09       Impact factor: 11.205

3.  Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.

Authors:  Garrett J Gross; Anna Hsu; John R Falck; Kasem Nithipatikom
Journal:  J Mol Cell Cardiol       Date:  2007-01-10       Impact factor: 5.000

Review 4.  Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.

Authors:  Christophe Morisseau; Bruce D Hammock
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012-09-27       Impact factor: 13.820

Review 5.  Role of oxylipins in cardiovascular diseases.

Authors:  Mohammed A Nayeem
Journal:  Acta Pharmacol Sin       Date:  2018-06-07       Impact factor: 6.150

6.  Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spontaneous labor.

Authors:  Krishna Rao Maddipati; Roberto Romero; Tinnakorn Chaiworapongsa; Sen-Lin Zhou; Zhonghui Xu; Adi L Tarca; Juan Pedro Kusanovic; Hernan Munoz; Kenneth V Honn
Journal:  FASEB J       Date:  2014-07-24       Impact factor: 5.191

7.  Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

Authors:  Garrett J Gross; Kathryn M Gauthier; Jeannine Moore; John R Falck; Bruce D Hammock; William B Campbell; Kasem Nithipatikom
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-04-25       Impact factor: 4.733

8.  Lycopus maackianus Makino MeOH Extract Exhibits Antioxidant and Anti-Neuroinflammatory Effects in Neuronal Cells and Zebrafish Model.

Authors:  Hwan Lee; Zhiming Liu; Linsha Dong; Sun Hee Cheong; Dong-Sung Lee
Journal:  Antioxidants (Basel)       Date:  2022-03-31

9.  The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo.

Authors:  Jessica A Wray; Mary C Sugden; Darryl C Zeldin; Gemma K Greenwood; Salma Samsuddin; Laura Miller-Degraff; J Alyce Bradbury; Mark J Holness; Timothy D Warner; David Bishop-Bailey
Journal:  PLoS One       Date:  2009-10-12       Impact factor: 3.240

10.  Expression of arachidonic acid-metabolizing cytochrome P450s in human megakaryocytic Dami cells.

Authors:  Yazun Bashir Jarrar; Jae-Gook Shin; Su-Jun Lee
Journal:  In Vitro Cell Dev Biol Anim       Date:  2013-05-31       Impact factor: 2.416
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.