| Literature DB >> 16839790 |
Courtney Karner1, Keith A Wharton, Thomas J Carroll.
Abstract
In addition to being polarized along their apical/basal axis, cells composing most (if not all) organs are also polarized in a plane vertical to the A/B axis. Recent studies indicate that this so-called planar cell polarity (PCP) plays an essential role in the formation of multiple organ systems regulating directed cell migrations, polarized cell division and proper differentiation. In this review we will discuss the molecular mechanisms regulating PCP, including the hypothesized roles for Wnt ligands in this process, and its roles in vertebrate organogenesis.Entities:
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Year: 2006 PMID： 16839790 DOI： 10.1016/j.semcdb.2006.05.003
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727