| Literature DB >> 16839774 |
Robert A Ross1, Barbara A Spengler.
Abstract
Human neuroblastoma is an embryonic cancer of the neural crest. Cellular heterogeneity is a characteristic feature of both tumors and derived cell lines. Recent studies have revealed that both cell lines and tumors contain cancer stem cells. In culture, these cells are self-renewing, multipotent, and highly malignant; in tumors their frequency correlates with a worse prognosis. Their identification and characterization should now permit a targeted approach to more effective treatment of this often fatal childhood cancer.Entities:
Mesh:
Year: 2006 PMID: 16839774 DOI: 10.1016/j.semcancer.2006.04.006
Source DB: PubMed Journal: Semin Cancer Biol ISSN: 1044-579X Impact factor: 15.707