Literature DB >> 16839764

A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).

Peter Bach1, Karolina Nilsson, Andreas Wållberg, Udo Bauer, Lance G Hammerland, Alecia Peterson, Tor Svensson, Krister Osterlund, David Karis, Maria Boije, David Wensbo.   

Abstract

Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.

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Year:  2006        PMID： 16839764     DOI： 10.1016/j.bmcl.2006.06.079

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

Authors:  Santosh S Kulkarni; Mu-Fa Zou; Jianjing Cao; Jeffrey R Deschamps; Alice L Rodriguez; P Jeffrey Conn; Amy Hauck Newman
Journal:  J Med Chem       Date:  2009-06-11       Impact factor: 7.446

2.  Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.

Authors:  Peng Zhang; Mu-Fa Zou; Alice L Rodriguez; P Jeffrey Conn; Amy Hauck Newman
Journal:  Bioorg Med Chem       Date:  2010-03-27       Impact factor: 3.641

3.  Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.

Authors:  Akito Yasuhara; Shigeyuki Chaki
Journal:  Open Med Chem J       Date:  2010-05-27
  3 in total

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