| Literature DB >> 16839124 |
Lijian Chen1, Young Mi Kim, David J Kucera, Katheryn E Harrison, Sogole Bahmanyar, Jill M Scott, Daniel Yazbeck.
Abstract
A Claisen rearrangement/iodolactamization sequence starting from commercially available trifluoroacetaldehyde methyl hemiacetal, followed by a classical chemical resolution, provided enantiomerically pure 4,4-difluoro-3,3-dimethylproline (S)-1. No hazardous fluorination reagents were used, and the overall yield over 12 steps was greater than 28%.Entities:
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Year: 2006 PMID： 16839124 DOI： 10.1021/jo060057p
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354