OBJECTIVE: Kathmandu tricycle taxi drivers, whose environmental lead (Pb) exposure is ascribable mainly to vehicular exhaust, were studied to examine a dose-response relationship between blood Pb (Pb-B) and serum erythropoietin (sEPO) concentrations. METHODS: Subjects were 27 drivers and 9 non-drivers. They were non-anemic healthy men with normal renal function. Pb-B was measured by an atomic absorption spectrometer with a graphite furnace, and sEPO was determined with a sandwich-type enzyme-linked immunosorbent assay. RESULTS: sEPO levels in drivers were lower than those of non-drivers, while Pb-B levels in drivers were higher than those of non-drivers. There was an inverse relationship between Pb-B and sEPO. CONCLUSIONS: The data suggest that Pb inhibits renal EPO production in a dose-dependent manner in persons with subclinical Pb toxicity. sEPO may serve as an early biochemical marker of subclinical Pb toxicity.
OBJECTIVE: Kathmandu tricycle taxi drivers, whose environmental lead (Pb) exposure is ascribable mainly to vehicular exhaust, were studied to examine a dose-response relationship between blood Pb (Pb-B) and serum erythropoietin (sEPO) concentrations. METHODS: Subjects were 27 drivers and 9 non-drivers. They were non-anemic healthy men with normal renal function. Pb-B was measured by an atomic absorption spectrometer with a graphite furnace, and sEPO was determined with a sandwich-type enzyme-linked immunosorbent assay. RESULTS:sEPO levels in drivers were lower than those of non-drivers, while Pb-B levels in drivers were higher than those of non-drivers. There was an inverse relationship between Pb-B and sEPO. CONCLUSIONS: The data suggest that Pb inhibits renal EPO production in a dose-dependent manner in persons with subclinical Pbtoxicity. sEPO may serve as an early biochemical marker of subclinical Pbtoxicity.
Authors: P Factor-Litvak; V Slavkovich; X Liu; D Popovac; E Preteni; S Capuni-Paracka; S Hadzialjevic; V Lekic; N LoIacono; J Kline; J Graziano Journal: Environ Health Perspect Date: 1998-06 Impact factor: 9.031
Authors: Funmi Apantaku-Onayemi; William Baldyga; Shaffdeen Amuwo; Adedeji Adefuye; Terry Mason; Robin Mitchell; Daniel S Blumenthal Journal: J Health Care Poor Underserved Date: 2012-05
Authors: Pashko R Camaj; Joseph H Graziano; Emine Preteni; Dusan Popovac; Nancy Loiacono; Olgica Balac; Pam Factor-Litvak Journal: J Environ Public Health Date: 2020-12-28