| Literature DB >> 16837197 |
Akira Tanaka1, Kouji Hattori, Kiyoshi Taniguchi, Osamu Okitsu, Seiichiro Tabuchi, Mie Nishio, Yasunori Nagakura, Noriaki Maeda, Hidetsugu Murai, Jiro Seki.
Abstract
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-prostanoid PGI2 mimetic with good oral bioavailability.Entities:
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Year: 2006 PMID： 16837197 DOI： 10.1016/j.bmcl.2006.06.076
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823