Literature DB >> 1683706

Detailed physical map of human chromosomal region 11q12-13 shows high meiotic recombination rate around the MEN1 locus.

M Janson1, C Larsson, B Werelius, C Jones, T Glaser, Y Nakamura, C P Jones, M Nordenskjöld.   

Abstract

We have constructed a physical map of the region q12-13 on chromosome 11 by combining data generated from a panel of radiation-reduced somatic cell hybrids and pulsed-field gel electrophoresis (PFGE). Twenty different genetic markers have been sublocalized and ordered within this region and a total of 8.0 megabases has been mapped in detail using rare-cutting restriction endonucleases and PFGE. In two instances, the long-range restriction PFGE map spans the total distance between pairs of loci that have been previously mapped by genetic linkage in reference families. Comparison of this physical map with the available linkage map indicates a great variation in the recombination frequency over the region. The recombination rate is higher than expected, particularly for markers flanking the MEN1 region. Thus, for the closest pair of linked markers on the centromeric side, one centimorgan corresponds to approximately 300 kilobases, and for markers on the telomeric side, one centimorgan corresponds to approximately 350-600 kilobases.

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Year:  1991        PMID： 1683706      PMCID： PMC52979          DOI： 10.1073/pnas.88.23.10609

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  40 in total

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Review 4.  CpG-rich islands and the function of DNA methylation.

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6.  Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.

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9.  Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism.

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4.  Meiotic recombination break points resolve at high rates at the 5' end of a maize coding sequence.

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5.  An interstitial telomere array proximal to the distal telomere of mouse chromosome 13.

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6.  A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13.

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7.  Genetic screening to identify the gene carrier in Italian and German kindreds affected by multiple endocrine neoplasia type 1 (MEN 1) syndrome.

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9.  Isolation and mapping of polymorphic cosmid clones used for sublocalization of the multiple endocrine neoplasia type 1 (MEN1) locus.

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10.  Mapping eight new polymorphisms in 11q13 in the vicinity of multiple endocrine neoplasia type 1: identification of a new distal recombinant.

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