BACKGROUND:Depression is common in patients with diabetes, but it is often inadequately treated within primary care. Competing clinical demands and treatment resistance may make it especially difficult to improve depressive symptoms in patients with diabetes who have multiple complications. OBJECTIVE: To determine whether a collaborative care intervention for depression would be as effective in patients with diabetes who had 2 or more complications as in patients with diabetes who had fewer complications. DESIGN: The Pathways Study was a randomized control trial comparing collaborative care case management for depression and usual primary care. This secondary analysis compared outcomes in patients with 2 or more complications to patients with fewer complications. PATIENTS: Three hundred and twenty-nine patients with diabetes and comorbid depression were recruited through primary care clinics of a large prepaid health plan. MEASUREMENTS: Depression was assessed at baseline, 3, 6, and 12 months with the 20-item depression scale from the Hopkins Symptom Checklist. Diabetes complications were determined from automated patient records. RESULTS: The Pathways collaborative care intervention was significantly more successful at reducing depressive symptoms than usual primary care in patients with diabetes who had 2 or more complications. Patients with fewer than 2 complications experienced similar reductions in depressive symptoms in both intervention and usual care. CONCLUSION:Patients with depression and diabetes who have multiple complications may benefit most from collaborative care for depression. These findings suggest that with appropriate intervention depression can be successfully treated in patients with diabetes who have the highest severity of medical problems.
RCT Entities:
BACKGROUND:Depression is common in patients with diabetes, but it is often inadequately treated within primary care. Competing clinical demands and treatment resistance may make it especially difficult to improve depressive symptoms in patients with diabetes who have multiple complications. OBJECTIVE: To determine whether a collaborative care intervention for depression would be as effective in patients with diabetes who had 2 or more complications as in patients with diabetes who had fewer complications. DESIGN: The Pathways Study was a randomized control trial comparing collaborative care case management for depression and usual primary care. This secondary analysis compared outcomes in patients with 2 or more complications to patients with fewer complications. PATIENTS: Three hundred and twenty-nine patients with diabetes and comorbid depression were recruited through primary care clinics of a large prepaid health plan. MEASUREMENTS: Depression was assessed at baseline, 3, 6, and 12 months with the 20-item depression scale from the Hopkins Symptom Checklist. Diabetes complications were determined from automated patient records. RESULTS: The Pathways collaborative care intervention was significantly more successful at reducing depressive symptoms than usual primary care in patients with diabetes who had 2 or more complications. Patients with fewer than 2 complications experienced similar reductions in depressive symptoms in both intervention and usual care. CONCLUSION:Patients with depression and diabetes who have multiple complications may benefit most from collaborative care for depression. These findings suggest that with appropriate intervention depression can be successfully treated in patients with diabetes who have the highest severity of medical problems.
Authors: Madhukar H Trivedi; A John Rush; Stephen R Wisniewski; Andrew A Nierenberg; Diane Warden; Louise Ritz; Grayson Norquist; Robert H Howland; Barry Lebowitz; Patrick J McGrath; Kathy Shores-Wilson; Melanie M Biggs; G K Balasubramani; Maurizio Fava Journal: Am J Psychiatry Date: 2006-01 Impact factor: 18.112
Authors: Gregory E Simon; Wayne J Katon; Elizabeth H B Lin; Evette Ludman; Michael VonKorff; Paul Ciechanowski; Bessie A Young Journal: Gen Hosp Psychiatry Date: 2005 Sep-Oct Impact factor: 3.238
Authors: Evette J Ludman; Wayne Katon; Joan Russo; Michael Von Korff; Gregory Simon; Paul Ciechanowski; Elizabeth Lin; Terry Bush; Edward Walker; Bessie Young Journal: Gen Hosp Psychiatry Date: 2004 Nov-Dec Impact factor: 3.238
Authors: John W Williams; Wayne Katon; Elizabeth H B Lin; Polly H Nöel; Jason Worchel; John Cornell; Linda Harpole; Bridget A Fultz; Enid Hunkeler; Virginia S Mika; Jürgen Unützer Journal: Ann Intern Med Date: 2004-06-15 Impact factor: 25.391
Authors: Wayne J Katon; Michael Von Korff; Elizabeth H B Lin; Greg Simon; Evette Ludman; Joan Russo; Paul Ciechanowski; Edward Walker; Terry Bush Journal: Arch Gen Psychiatry Date: 2004-10
Authors: Cynthia M Boyd; Christine S Ritchie; Edmond F Tipton; Stephanie A Studenski; Darryl Wieland Journal: Aging Clin Exp Res Date: 2008-06 Impact factor: 3.636
Authors: Dimitry S Davydow; Joan E Russo; Evette Ludman; Paul Ciechanowski; Elizabeth H B Lin; Michael Von Korff; Malia Oliver; Wayne J Katon Journal: Psychosomatics Date: 2011 Mar-Apr Impact factor: 2.386
Authors: Wayne J Katon; Joan E Russo; Michael Von Korff; Elizabeth H B Lin; Evette Ludman; Paul S Ciechanowski Journal: Diabetes Care Date: 2008-03-10 Impact factor: 19.112
Authors: Therese S Richmond; Judd E Hollander; Theimann H Ackerson; Keith Robinson; Vicente Gracias; Justine Shults; Jay Amsterdam Journal: Nurs Res Date: 2007 Jul-Aug Impact factor: 2.381