Literature DB >> 16835836

Gamma-aminobutyric acid (GABA) and cell proliferation: focus on cancer cells.

M Watanabe1, K Maemura, K Oki, N Shiraishi, Y Shibayama, K Katsu.   

Abstract

In addition to its role in the adult mammalian nervous system as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) is involved in the proliferation, differentiation, and migration of several kinds of cells including cancer cells. GABA is synthesized predominantly from glutamate by glutamate decarboxylase and exerts its effects via ionotropic GABA(A) receptors and/or metabotropic GABA(B) receptors. In this review, the current state of knowledge regarding the role of the GABAergic system in peripheral nonneuronal cell proliferation is described, and recent advances in elucidation of the mechanisms leading to cell proliferation are discussed.

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Year:  2006        PMID： 16835836     DOI： 10.14670/HH-21.1135

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  25 in total

1.  Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.

Authors:  Ka-Po Tse; Wen-Hui Su; Kai-Ping Chang; Ngan-Ming Tsang; Chia-Jung Yu; Petrus Tang; Lee-Chu See; Chuen Hsueh; Min-Lee Yang; Sheng-Po Hao; Hong-Yi Li; Ming-Hsi Wang; Li-Ping Liao; Lih-Chyang Chen; Sheue-Rong Lin; Timothy J Jorgensen; Yu-Sun Chang; Yin Yao Shugart
Journal:  Am J Hum Genet       Date:  2009-08-06       Impact factor: 11.025

2.  Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid.

Authors:  Anne K Bergfeld; Oliver M T Pearce; Sandra L Diaz; Tho Pham; Ajit Varki
Journal:  J Biol Chem       Date:  2012-06-12       Impact factor: 5.157

3.  Gamma-aminobutyric Acid Type A Receptor Subunit Delta as a Potential Therapeutic Target in Gastric Cancer.

Authors:  Koichi Sawaki; Mitsuro Kanda; Hayato Baba; Yoshikuni Inokawa; Norifumi Hattori; Masamichi Hayashi; Chie Tanaka; Yasuhiro Kodera
Journal:  Ann Surg Oncol       Date:  2022-09-20       Impact factor: 4.339

Review 4.  GABA increases Ca2+ in cerebellar granule cell precursors via depolarization: implications for proliferation.

Authors:  Kathleen A Dave; Angélique Bordey
Journal:  IUBMB Life       Date:  2009-05       Impact factor: 3.885

Review 5.  GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches.

Authors:  Stephanie Z Young; Angélique Bordey
Journal:  Physiology (Bethesda)       Date:  2009-06

Review 6.  The Metabolic Interplay between Cancer and Other Diseases.

Authors:  Anne Le; Sunag Udupa; Cissy Zhang
Journal:  Trends Cancer       Date:  2019-11-21

7.  Role of the nervous system in cancer metastasis.

Authors:  Sha Li; Yanlai Sun; Dongwei Gao
Journal:  Oncol Lett       Date:  2013-01-31       Impact factor: 2.967

8.  Suppression of Human Liver Cancer Cell Migration and Invasion via the GABAA Receptor.

Authors:  Zhi-Ao Chen; Mei-Yan Bao; Yong-Fen Xu; Ruo-Peng Zha; Hai-Bing Shi; Tao-Yang Chen; Xiang-Huo He
Journal:  Cancer Biol Med       Date:  2012-06       Impact factor: 4.248

9.  Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer.

Authors:  Xiaoxue Zhang; Rong Zhang; Yuanjie Zheng; Jianfei Shen; Dakai Xiao; Jin Li; Xiaoshun Shi; Liyan Huang; Hailing Tang; Jun Liu; Jianxing He; Haibo Zhang
Journal:  J Transl Med       Date:  2013-04-24       Impact factor: 5.531

10.  GABA A receptor π subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia.

Authors:  Junjie Lu; Qian Zhang; Dongmei Tan; Wenping Luo; Hai Zhao; Jing Ma; Hao Liang; Yi Tan
Journal:  Int J Mol Med       Date:  2016-05-25       Impact factor: 4.101
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