| Literature DB >> 16835089 |
Khalijah Awang1, Mat Ropi Mukhtar, A Hamid A Hadi, Marc Litaudon, Jalifah Latip, Noor Rain Abdullah.
Abstract
The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extract also exhibited antiplasmodial activity (IC50<8 microg mL-1). The structures of the novel compounds were elucidated by spectroscopic methods, notably 2D NMR and HRMS.Entities:
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Year: 2006 PMID： 16835089 DOI： 10.1080/14786410500183944
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861