| Literature DB >> 16834993 |
T Fournier1, V Tsatsaris, K Handschuh, D Evain-Brion.
Abstract
The discovery of the peroxisome proliferator-activated receptors (PPARs) in 1990s provided new insights in understanding the mechanisms involved in the control of energy homeostasis and in cell differentiation, proliferation, apoptosis and the inflammatory process. The PPARs became thus an exciting therapeutic target for diabetes, metabolic syndrome, atherosclerosis, and cancer. Unexpectedly, genetic studies performed in mice established that PPARgamma are essential for placental development. After a brief description of structural and functional features of PPARs, we will summarize in this review the most recent results concerning expression and the role of PPARs in placenta and of PPARgamma in human trophoblastic cells in particular.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16834993 DOI： 10.1016/j.placenta.2006.04.009
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481