Literature DB >> 1683349

Adhesion molecules on murine lymphokine-activated killer cells responsible for target cell killing: a role of CD2.

K Kato1, T Tanabe, H Yagita, T Agatsuma, H Hojo, Y Hashimoto.   

Abstract

Lymphokine-activated killer (LAK) cells were induced from C57BL/6 mouse spleen cells and the effects of culture time on the expression of cell surface phenotypes and cytotoxic activity of LAK cells were determined. The expression of CD2 remarkably decreased after culture of LAK cells for 30 days, while LFA-1, a principal adhesion molecule in LAK cells, and CD3 were not changed by the culture. LAK cells cultured for 90 days completely lost CD2. In accordance with the decrease of CD2, the cytotoxic activity of LAK cells declined but a certain leven was retained even after the complete loss of CD2. The established LAK cell clones were also strongly positive for the expression of LFA-1 but negative for CD2. When the LAK cell clones were transfected with the CD2 cDNA, they started to express CD2 on their cell surface and to show greater binding ability and stronger cytotoxicity to target tumor cells. These results indicated that CD2 plays a role as an adhesion molecule responsible for target cell killing in murine LAK cells.

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Year:  1991        PMID： 1683349      PMCID： PMC5918261          DOI： 10.1111/j.1349-7006.1991.tb01768.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


lymphokine‐activated killer interleukin 2 lymphocyte function‐associated antigen asialoGM1 T cell receptor cytotoxic T lymphocyte intercellular adhesion molecule monoclonal antibody fluorescein isothiocyanate fluorescein diacetate hydroethidine conjugate‐forming cells
  28 in total

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Authors:  Y Hashimoto; H Sudo
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Journal:  Cell Immunol       Date:  1985-08       Impact factor: 4.868

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Authors:  S C Meuer; R E Hussey; M Fabbi; D Fox; O Acuto; K A Fitzgerald; J C Hodgdon; J P Protentis; S F Schlossman; E L Reinherz
Journal:  Cell       Date:  1984-04       Impact factor: 41.582

6.  Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen.

Authors:  S Koyasu; T Lawton; D Novick; M A Recny; R F Siliciano; B P Wallner; E L Reinherz
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7.  Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.

Authors:  D Davignon; E Martz; T Reynolds; K Kürzinger; T A Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

Review 8.  The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition.

Authors:  M W Makgoba; M E Sanders; S Shaw
Journal:  Immunol Today       Date:  1989-12

9.  Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).

Authors:  M L Plunkett; M E Sanders; P Selvaraj; M L Dustin; T A Springer
Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307

10.  Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.

Authors:  M L Dustin; M E Sanders; S Shaw; T A Springer
Journal:  J Exp Med       Date:  1987-03-01       Impact factor: 14.307
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  3 in total

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2.  Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production.

Authors:  Y Itoh; Y Koshita; M Takahashi; N Watanabe; Y Kohgo; Y Niitsu
Journal:  Cancer Immunol Immunother       Date:  1995-02       Impact factor: 6.968

3.  Characterization of transendothelial migratory lymphokine-activated killer cells.

Authors:  K Nakano; M Eura; K Chikamatsu; K Masuyama; T Ishikawa
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  3 in total

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