Literature DB >> 16832504

Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif.

Sung Kon Ko1, Hwan Jong Jang, Eunha Kim, Seung Bum Park.   

Abstract

A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16832504     DOI： 10.1039/b606341a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents.

Authors:  Zhiming Wang; Sabrina Castellano; Sape S Kinderman; Christian E Argueta; Anwar B Beshir; Gabriel Fenteany; Ohyun Kwon
Journal:  Chemistry       Date:  2010-11-09       Impact factor: 5.236

2.  Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides.

Authors:  Farman Ullah; Thiwanka Samarakoon; Alan Rolfe; Ryan D Kurtz; Paul R Hanson; Michael G Organ
Journal:  Chemistry       Date:  2010-09-24       Impact factor: 5.236

3.  Metathesis Cascade Strategies (ROM-RCM-CM): A DOS approach to Skeletally Diverse Sultams.

Authors:  Kyu Ok Jeon; Dinesh Rayabarapu; Alan Rolfe; Kelly Volp; Iman Omar; Paul R Hanson
Journal:  Tetrahedron       Date:  2009-06-27       Impact factor: 2.457

4.  The Diels-Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC).

Authors:  Thomas Hurrle; Franziska Gläser; Manuel C Bröhmer; Martin Nieger; Stefan Bräse
Journal:  ChemistryOpen       Date:  2021-05       Impact factor: 2.630

5.  Crystal structures of ethyl 6-(4-methyl-phen-yl)-4-oxo-4H-chromene-2-carboxyl-ate and ethyl 6-(4-fluoro-phen-yl)-4-oxo-4H-chromene-2-carboxyl-ate.

Authors:  Ligia R Gomes; John Nicolson Low; Carlos Fernandes; Alexandra Gaspar; Fernanda Borges
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-01-01

6.  β-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.

Authors:  Chanwoo Kim; Jinjoo Jung; Truong T Tung; Seung Bum Park
Journal:  Chem Sci       Date:  2015-12-15       Impact factor: 9.825

Review 7.  Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery.

Authors:  Ian Collins; Alan M Jones
Journal:  Molecules       Date:  2014-10-27       Impact factor: 4.411

8.  Ionic Liquids and Ohmic Heating in Combination for Pd-catalyzed Cross-coupling Reactions: Sustainable Synthesis of Flavonoids.

Authors:  Vera L M Silva; Raquel G Soengas; Artur M S Silva
Journal:  Molecules       Date:  2020-03-29       Impact factor: 4.411
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.